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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1985 1
1989 1
1992 1
1993 1
1996 1
1999 1
2000 1
2002 1
2004 2
2010 1
2011 5
2012 2
2013 3
2014 5
2015 6
2016 4
2017 1
2018 1
2019 5
2020 6
2021 2
2022 2
2023 3
2024 0

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54 results

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Page 1
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer.
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164. doi: 10.1056/NEJMoa1611310. Epub 2016 Oct 7. N Engl J Med. 2016. PMID: 27717299 Free article. Clinical Trial.
Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling.
Holze J, Bermudez M, Pfeil EM, Kauk M, Bödefeld T, Irmen M, Matera C, Dallanoce C, De Amici M, Holzgrabe U, König GM, Tränkle C, Wolber G, Schrage R, Mohr K, Hoffmann C, Kostenis E, Bock A. Holze J, et al. ACS Pharmacol Transl Sci. 2020 Sep 2;3(5):859-867. doi: 10.1021/acsptsci.0c00069. eCollection 2020 Oct 9. ACS Pharmacol Transl Sci. 2020. PMID: 33073186 Free PMC article.
Allosteric coupling describes a reciprocal process whereby G-protein-coupled receptors (GPCRs) relay ligand-induced conformational changes from the extracellular binding pocket to the intracellular signaling surface. ...We demonstrate that stepwise shortening of their chem …
Allosteric coupling describes a reciprocal process whereby G-protein-coupled receptors (GPCRs) relay ligand-induced conformational ch …
Strategies for the discovery of biased GPCR ligands.
Bermudez M, Nguyen TN, Omieczynski C, Wolber G. Bermudez M, et al. Drug Discov Today. 2019 Apr;24(4):1031-1037. doi: 10.1016/j.drudis.2019.02.010. Epub 2019 Mar 1. Drug Discov Today. 2019. PMID: 30831262 Review.
G-protein-coupled receptors (GPCRs) represent important drug targets with complex pharmacological characteristics. ...We show different approaches for biased ligand discovery in the example of G-protein-biased opioid analgesics and discuss possibilities to design bi …
G-protein-coupled receptors (GPCRs) represent important drug targets with complex pharmacological characteristics. ...We show differe …
Mind the Gap-Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence.
Noonan T, Denzinger K, Talagayev V, Chen Y, Puls K, Wolf CA, Liu S, Nguyen TN, Wolber G. Noonan T, et al. Pharmaceuticals (Basel). 2022 Oct 22;15(11):1304. doi: 10.3390/ph15111304. Pharmaceuticals (Basel). 2022. PMID: 36355476 Free PMC article. Review.
G protein-coupled receptors (GPCRs) are amongst the most pharmaceutically relevant and well-studied protein targets, yet unanswered questions in the field leave significant gaps in our understanding of their nuanced structure and function. ...
G protein-coupled receptors (GPCRs) are amongst the most pharmaceutically relevant and well-studied protein targets, yet unanswered q …
Step-in dosing of bosutinib in pts with chronic phase chronic myeloid leukemia (CML) after second-generation tyrosine kinase inhibitor (TKI) therapy: results of the Bosutinib Dose Optimization (BODO) Study.
Isfort S, Manz K, Teichmann LL, Crysandt M, Burchert A, Hochhaus A, Saussele S, Kiani A, Göthert JR, Illmer T, Schafhausen P, Al-Ali HK, Stegelmann F, Hänel M, Pfeiffer T, Giagounidis A, Franke GN, Koschmieder S, Fabarius A, Ernst T, Warnken-Uhlich M, Wolber U, Kohn D, Pfirrmann M, Wolf D, Brümmendorf TH; German CML study group. Isfort S, et al. Ann Hematol. 2023 Oct;102(10):2741-2752. doi: 10.1007/s00277-023-05394-0. Epub 2023 Aug 18. Ann Hematol. 2023. PMID: 37592092 Free PMC article. Clinical Trial.
Melittin induces fusion of unilamellar phospholipid vesicles.
Morgan CG, Williamson H, Fuller S, Hudson B. Morgan CG, et al. Biochim Biophys Acta. 1983 Aug 10;732(3):668-74. doi: 10.1016/0005-2736(83)90245-6. Biochim Biophys Acta. 1983. PMID: 6871219
Fusion was detected using a new photochemical method (Morgan, C.G., Hudson, B. and Wolber, P. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 26-30) which monitors lipid mixing. ...
Fusion was detected using a new photochemical method (Morgan, C.G., Hudson, B. and Wolber, P. (1980) Proc. Natl. Acad. Sci. U. …
Structure versus function-The impact of computational methods on the discovery of specific GPCR-ligands.
Bermudez M, Wolber G. Bermudez M, et al. Bioorg Med Chem. 2015 Jul 15;23(14):3907-12. doi: 10.1016/j.bmc.2015.03.026. Epub 2015 Mar 14. Bioorg Med Chem. 2015. PMID: 25828056 Review.
The combination of experimental and in silico methods in the field of G protein coupled receptors (GPCRs) is indispensable. Despite recent groundbreaking achievements in GPCR crystallography, structural information for the vast majority of this physiologically important pr …
The combination of experimental and in silico methods in the field of G protein coupled receptors (GPCRs) is indispensable. Despite r …
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.
Bock A, Bermudez M, Krebs F, Matera C, Chirinda B, Sydow D, Dallanoce C, Holzgrabe U, De Amici M, Lohse MJ, Wolber G, Mohr K. Bock A, et al. J Biol Chem. 2016 Jul 29;291(31):16375-89. doi: 10.1074/jbc.M116.735431. Epub 2016 Jun 13. J Biol Chem. 2016. PMID: 27298318 Free PMC article.
G protein-coupled receptors constitute the largest family of membrane receptors and modulate almost every physiological process in humans. Binding of agonists to G protein-coupled receptors induces a shift from inactive to active receptor conformations. ...
G protein-coupled receptors constitute the largest family of membrane receptors and modulate almost every physiological process in hu …
High homogeneity of MMR deficiency in ovarian cancer.
Fraune C, Rosebrock J, Simon R, Hube-Magg C, Makrypidi-Fraune G, Kluth M, Büscheck F, Höflmayer D, Schmalfeldt B, Müller V, Wölber L, Witzel I, Paluchowski P, Wilke C, Heilenkötter U, von Leffern I, Clauditz TS, Wilczak W, Sauter G, Steurer S, Burandt E. Fraune C, et al. Gynecol Oncol. 2020 Mar;156(3):669-675. doi: 10.1016/j.ygyno.2019.12.031. Epub 2020 Jan 8. Gynecol Oncol. 2020. PMID: 31924330
Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP).
Seiter MA, Salcher S, Rupp M, Hagenbuchner J, Kiechl-Kohlendorfer U, Mortier J, Wolber G, Rollinger JM, Obexer P, Ausserlechner MJ. Seiter MA, et al. FEBS Open Bio. 2014 Jul 5;4:659-71. doi: 10.1016/j.fob.2014.07.001. eCollection 2014. FEBS Open Bio. 2014. PMID: 25161875 Free PMC article.
Most promising candidates of this plant were tested biochemically in vitro by a fluorescence polarization (FP) assay and in vivo via protein fragment complementation analysis (PCA). We identified the Diels Alder adduct Sanggenon G (SG1) as a novel, small-molecular weight i …
Most promising candidates of this plant were tested biochemically in vitro by a fluorescence polarization (FP) assay and in vivo via protein …
54 results