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Page 1
Showing results for first islet
Search for Firat Islek instead (1 results)
First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 3: Porcine islet product manufacturing and release testing criteria.
Rayat GR, Gazda LS, Hawthorne WJ, Hering BJ, Hosking P, Matsumoto S, Rajotte RV. Rayat GR, et al. Xenotransplantation. 2016 Jan-Feb;23(1):38-45. doi: 10.1111/xen.12225. Epub 2016 Feb 29. Xenotransplantation. 2016. PMID: 26923763
Thus, they are subject to applicable provisions of the law and as such, control of manufacturing as well as reproducibility and consistency of porcine islet products, safety of porcine islet products, and characterization of porcine islet products must be met …
Thus, they are subject to applicable provisions of the law and as such, control of manufacturing as well as reproducibility and consistency …
Pancreatic islet organoids-on-a-chip: how far have we gone?
Yin J, Meng H, Lin J, Ji W, Xu T, Liu H. Yin J, et al. J Nanobiotechnology. 2022 Jun 28;20(1):308. doi: 10.1186/s12951-022-01518-2. J Nanobiotechnology. 2022. PMID: 35764957 Free PMC article. Review.
For the research and treatment of DM, the platforms have been widely used to investigate the physiology and pathophysiology of islets. In this review, we first highlight how pancreatic islet organoids-on-a-chip have improved the reproducibility of stem cell d …
For the research and treatment of DM, the platforms have been widely used to investigate the physiology and pathophysiology of islets …
Intra-islet glucagon confers beta-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
Cabrera O, Ficorilli J, Shaw J, Echeverri F, Schwede F, Chepurny OG, Leech CA, Holz GG. Cabrera O, et al. J Biol Chem. 2022 Feb;298(2):101484. doi: 10.1016/j.jbc.2021.101484. Epub 2021 Dec 9. J Biol Chem. 2022. PMID: 34896391 Free PMC article.
We report that intra-islet glucagon secreted from alpha-cells signals through beta-cell glucagon and GLP-1 receptors (GcgR and GLP-1R), thereby conferring to rat islets their competence to exhibit first-phase glucose-stimulated insulin secretion (GSIS). Thus, …
We report that intra-islet glucagon secreted from alpha-cells signals through beta-cell glucagon and GLP-1 receptors (GcgR and GLP-1R …
Evolution of Islet Transplantation for the Last 30 Years.
Farney AC, Sutherland DE, Opara EC. Farney AC, et al. Pancreas. 2016 Jan;45(1):8-20. doi: 10.1097/MPA.0000000000000391. Pancreas. 2016. PMID: 26658037 Review.
In this article, we will review the changes that have occurred in islet transplantation at the birth of Pancreas 30 years ago. The first attempts at beta-cell replacement in humans, pancreas and islet transplantation, were performed in the 1960s and 1970s. .. …
In this article, we will review the changes that have occurred in islet transplantation at the birth of Pancreas 30 years ago. The …
Application of microfluidic technology to pancreatic islet research: first decade of endeavor.
Wang Y, Lo JF, Mendoza-Elias JE, Adewola AF, Harvat TA, Kinzer KP, Lee D, Qi M, Eddington DT, Oberholzer J. Wang Y, et al. Bioanalysis. 2010 Oct;2(10):1729-44. doi: 10.4155/bio.10.131. Bioanalysis. 2010. PMID: 21083325 Review.
The spatio-temporal resolutions of these analyses have been improved through enhanced flow control, valves and compartmentalization. For the first time, this review provides an overview of current devices used in islet studies and analyzes their strengths and experi …
The spatio-temporal resolutions of these analyses have been improved through enhanced flow control, valves and compartmentalization. For the …
From insulin injections to islet transplantation: An overview of the journey.
Paget MB, Murray HE, Bailey CJ, Downing R. Paget MB, et al. Diabetes Obes Metab. 2022 Jan;24 Suppl 1:5-16. doi: 10.1111/dom.14526. Epub 2021 Oct 26. Diabetes Obes Metab. 2022. PMID: 34431589 Review.
When, in 1869, Paul Langerhans detected the "islands of tissue" in the pancreas, he took the first step on a journey towards islet transplantation as a treatment for type 1 diabetes. ...This review highlights major milestones along that journey involving whole pancr …
When, in 1869, Paul Langerhans detected the "islands of tissue" in the pancreas, he took the first step on a journey towards islet …
Clinical islet transplantation: is the future finally now?
Pepper AR, Bruni A, Shapiro AMJ. Pepper AR, et al. Curr Opin Organ Transplant. 2018 Aug;23(4):428-439. doi: 10.1097/MOT.0000000000000546. Curr Opin Organ Transplant. 2018. PMID: 29847441 Review.
This chapter examines the current progress in islet transplantation while outlining the remaining limitations preventing this life-altering therapy's application to the broader T1DM population. RECENT FINDINGS: Islet transplantation has recently been demonstrated to …
This chapter examines the current progress in islet transplantation while outlining the remaining limitations preventing this life-al …
Total Pancreatectomy with Autologous Islet Cell Transplantation.
Schrope B. Schrope B. Gastrointest Endosc Clin N Am. 2018 Oct;28(4):605-618. doi: 10.1016/j.giec.2018.05.003. Epub 2018 Jul 13. Gastrointest Endosc Clin N Am. 2018. PMID: 30241647 Review.
First described in the early 1980s, total pancreatectomy with autologous islet cell transplantation for the treatment of chronic pancreatitis is still only offered in select centers worldwide. Indications, process details including surgery as well as islet is …
First described in the early 1980s, total pancreatectomy with autologous islet cell transplantation for the treatment of chron …
Is islet transplantation a realistic approach to curing diabetes?
Jin SM, Kim KW. Jin SM, et al. Korean J Intern Med. 2017 Jan;32(1):62-66. doi: 10.3904/kjim.2016.224. Epub 2017 Jan 1. Korean J Intern Med. 2017. PMID: 28049286 Free PMC article. Review.
With the long-awaited report of the first phase 3 clinical trial in 2016, allogeneic islet transplantation is now transitioning from an experimental to a proven therapy for type 1 diabetes with problematic hypoglycemia. ...Based on current evidence, this review focu …
With the long-awaited report of the first phase 3 clinical trial in 2016, allogeneic islet transplantation is now transitionin …
Pancreatic islet dysfunction in type 2 diabetes mellitus.
Hu F, Qiu X, Bu S. Hu F, et al. Arch Physiol Biochem. 2020 Jul;126(3):235-241. doi: 10.1080/13813455.2018.1510967. Epub 2018 Oct 6. Arch Physiol Biochem. 2020. PMID: 30293453 Review.
Compelling evidence suggests that accumulation of islet amyloid in the islets of Langerhans significantly contribute to beta-cell dysfunction and diabetes. ...Inflammatory changes, including accumulation of macrophages, have been documented in type 2 diabetic isl …
Compelling evidence suggests that accumulation of islet amyloid in the islets of Langerhans significantly contribute to beta-c …
8,208 results