Total Pancreatectomy with Autologous Islet Cell Transplantation

Beth Schrope

doi:10.1016/j.giec.2018.05.003

Total Pancreatectomy with Autologous Islet Cell Transplantation

Gastrointest Endosc Clin N Am. 2018 Oct;28(4):605-618. doi: 10.1016/j.giec.2018.05.003. Epub 2018 Jul 13.

Author

Beth Schrope¹

Affiliation

¹ Department of Surgery, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, 8th Floor, New York, NY 10032, USA. Electronic address: bs170@cumc.columbia.edu.

PMID: 30241647
DOI: 10.1016/j.giec.2018.05.003

Abstract

First described in the early 1980s, total pancreatectomy with autologous islet cell transplantation for the treatment of chronic pancreatitis is still only offered in select centers worldwide. Indications, process details including surgery as well as islet isolation, and results are reviewed. In addition, areas for further research to optimize results are identified.

Keywords: Autologous islet cell transplantation; Chronic pancreatitis; Islet isolation; Type 3c diabetes.

Publication types

Review

MeSH terms

Chronic Disease
Diabetes Mellitus / drug therapy
Diabetes Mellitus / etiology
Diabetes Mellitus / prevention & control*
Humans
Insulin / metabolism*
Insulin / therapeutic use
Islets of Langerhans / metabolism*
Islets of Langerhans Transplantation / methods*
Pancreatectomy* / adverse effects
Pancreatitis / surgery*
Patient Selection
Tissue Preservation / methods
Tissue and Organ Harvesting
Transplantation, Autologous

Substances

Insulin