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Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice.
Schaftenaar FH, van Dam AD, de Bruin G, Depuydt MAC, de Mol J, Amersfoort J, Douna H, Meijer M, Kröner MJ, van Santbrink PJ, Bernabé Kleijn MNA, van Puijvelde GHM, Florea BI, Slütter B, Foks AC, Bot I, Rensen PCN, Kuiper J. Schaftenaar FH, et al. Among authors: florea bi. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1346-1364. doi: 10.1161/ATVBAHA.123.319701. Epub 2024 Apr 25. Arterioscler Thromb Vasc Biol. 2024. PMID: 38660806
Targeted pH-dependent fluorescent activity-based cathepsin probes.
Hoogendoorn S, Habets KL, Passemard S, Kuiper J, van der Marel GA, Florea BI, Overkleeft HS. Hoogendoorn S, et al. Among authors: florea bi. Chem Commun (Camb). 2011 Sep 7;47(33):9363-5. doi: 10.1039/c1cc12947c. Epub 2011 Jul 18. Chem Commun (Camb). 2011. PMID: 21769329
A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities.
de Bruin G, Xin BT, Kraus M, van der Stelt M, van der Marel GA, Kisselev AF, Driessen C, Florea BI, Overkleeft HS. de Bruin G, et al. Among authors: florea bi. Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4199-203. doi: 10.1002/anie.201509092. Epub 2015 Oct 29. Angew Chem Int Ed Engl. 2016. PMID: 26511210
Receptor-mediated targeting of cathepsins in professional antigen presenting cells.
Hillaert U, Verdoes M, Florea BI, Saragliadis A, Habets KL, Kuiper J, Van Calenbergh S, Ossendorp F, van der Marel GA, Driessen C, Overkleeft HS. Hillaert U, et al. Among authors: florea bi. Angew Chem Int Ed Engl. 2009;48(9):1629-32. doi: 10.1002/anie.200805529. Angew Chem Int Ed Engl. 2009. PMID: 19156780
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites.
Geurink PP, van der Linden WA, Mirabella AC, Gallastegui N, de Bruin G, Blom AE, Voges MJ, Mock ED, Florea BI, van der Marel GA, Driessen C, van der Stelt M, Groll M, Overkleeft HS, Kisselev AF. Geurink PP, et al. Among authors: florea bi. J Med Chem. 2013 Feb 14;56(3):1262-75. doi: 10.1021/jm3016987. Epub 2013 Jan 28. J Med Chem. 2013. PMID: 23320547 Free PMC article.
145 results