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tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector.
Jain I, Kolesnik M, Kuznedelov K, Minakhin L, Morozova N, Shiriaeva A, Kirillov A, Medvedeva S, Livenskyi A, Kazieva L, Makarova KS, Koonin EV, Borukhov S, Severinov K, Semenova E. Jain I, et al. Among authors: livenskyi a. Sci Adv. 2024 Apr 26;10(17):eadl0164. doi: 10.1126/sciadv.adl0164. Epub 2024 Apr 24. Sci Adv. 2024. PMID: 38657076 Free PMC article.
Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection.
Burman N, Belukhina S, Depardieu F, Wilkinson RA, Skutel M, Santiago-Frangos A, Graham AB, Livenskyi A, Chechenina A, Morozova N, Zahl T, Henriques WS, Buyukyoruk M, Rouillon C, Shyrokova L, Kurata T, Hauryliuk V, Severinov K, Groseille J, Thierry A, Koszul R, Tesson F, Bernheim A, Bikard D, Wiedenheft B, Isaev A. Burman N, et al. Among authors: livenskyi a. bioRxiv [Preprint]. 2024 Jan 9:2024.01.02.573894. doi: 10.1101/2024.01.02.573894. bioRxiv. 2024. PMID: 38260645 Free PMC article. Preprint.
GNAT toxins evolve toward narrow tRNA target specificities.
Bikmetov D, Hall AMJ, Livenskyi A, Gollan B, Ovchinnikov S, Gilep K, Kim JY, Larrouy-Maumus G, Zgoda V, Borukhov S, Severinov K, Helaine S, Dubiley S. Bikmetov D, et al. Among authors: livenskyi a. Nucleic Acids Res. 2022 Jun 10;50(10):5807-5817. doi: 10.1093/nar/gkac356. Nucleic Acids Res. 2022. PMID: 35609997 Free PMC article.
Mechanism of translation inhibition by type II GNAT toxin AtaT2.
Ovchinnikov SV, Bikmetov D, Livenskyi A, Serebryakova M, Wilcox B, Mangano K, Shiriaev DI, Osterman IA, Sergiev PV, Borukhov S, Vazquez-Laslop N, Mankin AS, Severinov K, Dubiley S. Ovchinnikov SV, et al. Among authors: livenskyi a. Nucleic Acids Res. 2020 Sep 4;48(15):8617-8625. doi: 10.1093/nar/gkaa551. Nucleic Acids Res. 2020. PMID: 32597957 Free PMC article.