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Page 1
Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.
Conti S, Venturini V, Cañellas-Socias A, Cortina C, Abenza JF, Stephan-Otto Attolini C, Middendorp Guerra E, Xu CK, Li JH, Rossetti L, Stassi G, Roca-Cusachs P, Diz-Muñoz A, Ruprecht V, Guck J, Batlle E, Labernadie A, Trepat X. Conti S, et al. Among authors: batlle e. Nat Commun. 2024 Apr 18;15(1):3363. doi: 10.1038/s41467-024-47227-2. Nat Commun. 2024. PMID: 38637494 Free PMC article.
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy.
Álvarez-Varela A, Novellasdemunt L, Barriga FM, Hernando-Momblona X, Cañellas-Socias A, Cano-Crespo S, Sevillano M, Cortina C, Stork D, Morral C, Turon G, Slebe F, Jiménez-Gracia L, Caratù G, Jung P, Stassi G, Heyn H, Tauriello DVF, Mateo L, Tejpar S, Sancho E, Stephan-Otto Attolini C, Batlle E. Álvarez-Varela A, et al. Among authors: batlle e. Nat Cancer. 2022 Sep;3(9):1052-1070. doi: 10.1038/s43018-022-00402-0. Epub 2022 Jun 30. Nat Cancer. 2022. PMID: 35773527 Free article.
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells.
Cañellas-Socias A, Cortina C, Hernando-Momblona X, Palomo-Ponce S, Mulholland EJ, Turon G, Mateo L, Conti S, Roman O, Sevillano M, Slebe F, Stork D, Caballé-Mestres A, Berenguer-Llergo A, Álvarez-Varela A, Fenderico N, Novellasdemunt L, Jiménez-Gracia L, Sipka T, Bardia L, Lorden P, Colombelli J, Heyn H, Trepat X, Tejpar S, Sancho E, Tauriello DVF, Leedham S, Attolini CS, Batlle E. Cañellas-Socias A, et al. Among authors: batlle e. Nature. 2022 Nov;611(7936):603-613. doi: 10.1038/s41586-022-05402-9. Epub 2022 Nov 9. Nature. 2022. PMID: 36352230 Free article.
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.
Herpers B, Eppink B, James MI, Cortina C, Cañellas-Socias A, Boj SF, Hernando-Momblona X, Glodzik D, Roovers RC, van de Wetering M, Bartelink-Clements C, Zondag-van der Zande V, Mateos JG, Yan K, Salinaro L, Basmeleh A, Fatrai S, Maussang D, Lammerts van Bueren JJ, Chicote I, Serna G, Cabellos L, Ramírez L, Nuciforo P, Salazar R, Santos C, Villanueva A, Stephan-Otto Attolini C, Sancho E, Palmer HG, Tabernero J, Stratton MR, de Kruif J, Logtenberg T, Clevers H, Price LS, Vries RGJ, Batlle E, Throsby M. Herpers B, et al. Among authors: batlle e. Nat Cancer. 2022 Apr;3(4):418-436. doi: 10.1038/s43018-022-00359-0. Epub 2022 Apr 25. Nat Cancer. 2022. PMID: 35469014 Free article.
Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy.
Linares J, Sallent-Aragay A, Badia-Ramentol J, Recort-Bascuas A, Méndez A, Manero-Rupérez N, Re DL, Rivas EI, Guiu M, Zwick M, Iglesias M, Martinez-Ciarpaglini C, Tarazona N, Varese M, Hernando-Momblona X, Cañellas-Socias A, Orrillo M, Garrido M, Saoudi N, Elez E, Navarro P, Tabernero J, Gomis RR, Batlle E, Pisonero J, Cervantes A, Montagut C, Calon A. Linares J, et al. Among authors: batlle e. Nat Commun. 2023 Feb 10;14(1):746. doi: 10.1038/s41467-023-36334-1. Nat Commun. 2023. PMID: 36765091 Free PMC article.
A genome editing approach to study cancer stem cells in human tumors.
Cortina C, Turon G, Stork D, Hernando-Momblona X, Sevillano M, Aguilera M, Tosi S, Merlos-Suárez A, Stephan-Otto Attolini C, Sancho E, Batlle E. Cortina C, et al. Among authors: batlle e. EMBO Mol Med. 2017 Jul;9(7):869-879. doi: 10.15252/emmm.201707550. EMBO Mol Med. 2017. PMID: 28468934 Free PMC article.
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.
Whissell G, Montagni E, Martinelli P, Hernando-Momblona X, Sevillano M, Jung P, Cortina C, Calon A, Abuli A, Castells A, Castellvi-Bel S, Nacht AS, Sancho E, Stephan-Otto Attolini C, Vicent GP, Real FX, Batlle E. Whissell G, et al. Among authors: batlle e. Nat Cell Biol. 2014 Jul;16(7):695-707. doi: 10.1038/ncb2992. Epub 2014 Jun 22. Nat Cell Biol. 2014. PMID: 24952462 Free article.
Long-lived force patterns and deformation waves at repulsive epithelial boundaries.
Rodríguez-Franco P, Brugués A, Marín-Llauradó A, Conte V, Solanas G, Batlle E, Fredberg JJ, Roca-Cusachs P, Sunyer R, Trepat X. Rodríguez-Franco P, et al. Among authors: batlle e. Nat Mater. 2017 Oct;16(10):1029-1037. doi: 10.1038/nmat4972. Epub 2017 Sep 11. Nat Mater. 2017. PMID: 28892054 Free PMC article.
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration.
Pérez-González C, Ceada G, Greco F, Matejčić M, Gómez-González M, Castro N, Menendez A, Kale S, Krndija D, Clark AG, Gannavarapu VR, Álvarez-Varela A, Roca-Cusachs P, Batlle E, Vignjevic DM, Arroyo M, Trepat X. Pérez-González C, et al. Among authors: batlle e. Nat Cell Biol. 2021 Jul;23(7):745-757. doi: 10.1038/s41556-021-00699-6. Epub 2021 Jun 21. Nat Cell Biol. 2021. PMID: 34155382 Free PMC article.
145 results