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Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.
Radmand A, Kim H, Beyersdorf J, Dobrowolski CN, Zenhausern R, Paunovska K, Huayamares SG, Hua X, Han K, Loughrey D, Hatit MZC, Del Cid A, Ni H, Shajii A, Li A, Muralidharan A, Peck HE, Tiegreen KE, Jia S, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: santangelo pj. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307801120. doi: 10.1073/pnas.2307801120. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437539 Free PMC article.
A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.
Paunovska K, Sago CD, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE. Paunovska K, et al. Among authors: santangelo pj. Nano Lett. 2018 Mar 14;18(3):2148-2157. doi: 10.1021/acs.nanolett.8b00432. Epub 2018 Mar 5. Nano Lett. 2018. PMID: 29489381 Free PMC article.
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Gamboa Castro M, Anderson SE, Rudoltz TG, Lando GN, Munnilal Tiwari P, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV, Dahlman JE. Sago CD, et al. Among authors: santangelo pj. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9944-E9952. doi: 10.1073/pnas.1811276115. Epub 2018 Oct 1. Proc Natl Acad Sci U S A. 2018. PMID: 30275336 Free PMC article.
Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV.
Lindsay KE, Vanover D, Thoresen M, King H, Xiao P, Badial P, Araínga M, Park SB, Tiwari PM, Peck HE, Blanchard EL, Feugang JM, Olivier AK, Zurla C, Villinger F, Woolums AR, Santangelo PJ. Lindsay KE, et al. Among authors: santangelo pj. Mol Ther. 2020 Mar 4;28(3):805-819. doi: 10.1016/j.ymthe.2020.01.002. Epub 2020 Jan 10. Mol Ther. 2020. PMID: 31995741 Free PMC article.
Increased PIP3 activity blocks nanoparticle mRNA delivery.
Paunovska K, Da Silva Sanchez A, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman JE. Paunovska K, et al. Among authors: santangelo pj. Sci Adv. 2020 Jul 22;6(30):eaba5672. doi: 10.1126/sciadv.aba5672. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32743074 Free PMC article.
Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents.
Blanchard EL, Vanover D, Bawage SS, Tiwari PM, Rotolo L, Beyersdorf J, Peck HE, Bruno NC, Hincapie R, Michel F, Murray J, Sadhwani H, Vanderheyden B, Finn MG, Brinton MA, Lafontaine ER, Hogan RJ, Zurla C, Santangelo PJ. Blanchard EL, et al. Among authors: santangelo pj. Nat Biotechnol. 2021 Jun;39(6):717-726. doi: 10.1038/s41587-021-00822-w. Epub 2021 Feb 3. Nat Biotechnol. 2021. PMID: 33536629
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles.
Hatit MZC, Lokugamage MP, Dobrowolski CN, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: santangelo pj. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. Nat Nanotechnol. 2022. PMID: 35132167 Free PMC article.
90 results