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Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.
Radmand A, Kim H, Beyersdorf J, Dobrowolski CN, Zenhausern R, Paunovska K, Huayamares SG, Hua X, Han K, Loughrey D, Hatit MZC, Del Cid A, Ni H, Shajii A, Li A, Muralidharan A, Peck HE, Tiegreen KE, Jia S, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: dahlman je. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307801120. doi: 10.1073/pnas.2307801120. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437539 Free PMC article.
Increased PIP3 activity blocks nanoparticle mRNA delivery.
Paunovska K, Da Silva Sanchez A, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman JE. Paunovska K, et al. Among authors: dahlman je. Sci Adv. 2020 Jul 22;6(30):eaba5672. doi: 10.1126/sciadv.aba5672. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32743074 Free PMC article.
Therapeutic RNA Delivery for COVID and Other Diseases.
Dobrowolski C, Paunovska K, Hatit MZC, Lokugamage MP, Dahlman JE. Dobrowolski C, et al. Among authors: dahlman je. Adv Healthc Mater. 2021 Aug;10(15):e2002022. doi: 10.1002/adhm.202002022. Epub 2021 Mar 4. Adv Healthc Mater. 2021. PMID: 33661555 Free PMC article. Review.
Non-liver mRNA Delivery.
Loughrey D, Dahlman JE. Loughrey D, et al. Among authors: dahlman je. Acc Chem Res. 2022 Jan 4;55(1):13-23. doi: 10.1021/acs.accounts.1c00601. Epub 2021 Dec 3. Acc Chem Res. 2022. PMID: 34859663 Review.
Drug delivery systems for RNA therapeutics.
Paunovska K, Loughrey D, Dahlman JE. Paunovska K, et al. Among authors: dahlman je. Nat Rev Genet. 2022 May;23(5):265-280. doi: 10.1038/s41576-021-00439-4. Epub 2022 Jan 4. Nat Rev Genet. 2022. PMID: 34983972 Free PMC article. Review.
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles.
Hatit MZC, Lokugamage MP, Dobrowolski CN, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: dahlman je. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. Nat Nanotechnol. 2022. PMID: 35132167 Free PMC article.
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery.
Da Silva Sanchez AJ, Dobrowolski C, Cristian A, Echeverri ES, Zhao K, Hatit MZC, Loughrey D, Paunovska K, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: dahlman je. Nano Lett. 2022 Jun 22;22(12):4822-4830. doi: 10.1021/acs.nanolett.2c01133. Epub 2022 Jun 7. Nano Lett. 2022. PMID: 35671473
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery.
Dobrowolski C, Paunovska K, Schrader Echeverri E, Loughrey D, Da Silva Sanchez AJ, Ni H, Hatit MZC, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE. Dobrowolski C, et al. Among authors: dahlman je. Nat Nanotechnol. 2022 Aug;17(8):871-879. doi: 10.1038/s41565-022-01146-9. Epub 2022 Jun 30. Nat Nanotechnol. 2022. PMID: 35768613
69 results