Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury.
Su Y, Chen Z, Du H, Liu R, Wang W, Li H, Ning B.
Su Y, et al. Among authors: chen z.
FASEB J. 2019 Oct;33(10):10859-10871. doi: 10.1096/fj.201900743R. Epub 2019 Jul 2.
FASEB J. 2019.
PMID: 31266356
Moreover, we also verified the mechanism of A2s promoting synaptic formation and nerve growth. miR-21 is a switch to regulate the polarization of reactive astrocyte, and it promoted synapsis formation and nerites growth after acute ISCI.-Su, Y., Chen, Z., Du, H., Li …
Moreover, we also verified the mechanism of A2s promoting synaptic formation and nerve growth. miR-21 is a switch to regulate the polarizati …