Better than being aPARt: S. aureus itches to get close to sensory neurons

Zhe Chen; Sha Huang; Yanlin Su

doi:10.1016/j.chom.2023.12.011

Better than being aPARt: S. aureus itches to get close to sensory neurons

Cell Host Microbe. 2024 Jan 10;32(1):3-4. doi: 10.1016/j.chom.2023.12.011.

Authors

Zhe Chen¹, Sha Huang², Yanlin Su³

Affiliations

¹ School of Physical Education and Sports Science, South China Normal University, Guangzhou 510006, China.
² Research Center for Tissue Repair and Regeneration affiliated with the Medical Innovation Research Department, Chinese PLA General Hospital, Beijing 100853, China.
³ Research Center for Tissue Repair and Regeneration affiliated with the Medical Innovation Research Department, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: suyl1166@126.com.

PMID: 38211562
DOI: 10.1016/j.chom.2023.12.011

Abstract

In a recent issue of Cell, Deng et al. show that S. aureus serine protease V8 triggers itch, independent of inflammation, by activating sensory neurons through PAR1. This study presents mechanistic insights into pruritogenic bacteria and their interactions with sensory neurons while providing a possible approach for treating itch-related diseases.

Publication types

Comment

MeSH terms

Humans
Inflammation
Methicillin-Resistant Staphylococcus aureus*
Pruritus
Sensory Receptor Cells / physiology
Staphylococcus aureus*