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Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Hopkins SC, Toongsuwan S, Corriveau TJ, Watanabe T, Tsushima Y, Asada T, Lew R, Shi L, Zann V, Snowden TJ, van der Graaf PH, Darpo B, Searle GE, Rabiner EA, Wilding I, Szabo ST, Galluppi GR, Koblan KS. Hopkins SC, et al. Clin Pharmacol Ther. 2024 May 31. doi: 10.1002/cpt.3311. Online ahead of print. Clin Pharmacol Ther. 2024. PMID: 38822554
Computationally restoring the potency of a clinical antibody against Omicron.
Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW; Tri-lab COVID-19 Consortium; Lillo AM, Sundaram S, Bloom JD, Diamond MS, Crowe JE Jr, Carnahan RH, Faissol DM. Desautels TA, et al. Among authors: hopkins s. Nature. 2024 May;629(8013):878-885. doi: 10.1038/s41586-024-07385-1. Epub 2024 May 8. Nature. 2024. PMID: 38720086 Free PMC article.
Estimating heterogeneity of treatment effect in psychiatric clinical trials.
Siegel JS, Zhong J, Tomioka S, Ogirala A, Faraone SV, Szabo ST, Koblan KS, Hopkins SC. Siegel JS, et al. Among authors: hopkins sc. medRxiv [Preprint]. 2024 Apr 23:2024.04.23.24306211. doi: 10.1101/2024.04.23.24306211. medRxiv. 2024. PMID: 38712180 Free PMC article. Preprint.
1,334 results