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Genetic Silencing of AKT Induces Melanoma Cell Death via mTOR Suppression.
Parkman GL, Turapov T, Kircher DA, Burnett WJ, Stehn CM, O'Toole K, Culver KM, Chadwick AT, Elmer RC, Flaherty R, Stanley KA, Foth M, Lum DH, Judson-Torres RL, Friend JE, VanBrocklin MW, McMahon M, Holmen SL. Parkman GL, et al. Among authors: holmen sl. Mol Cancer Ther. 2024 Mar 4;23(3):301-315. doi: 10.1158/1535-7163.MCT-23-0474. Mol Cancer Ther. 2024. PMID: 37931033
AKT1 Activation Promotes Development of Melanoma Metastases.
Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW, McMahon M, Holmen SL. Cho JH, et al. Among authors: holmen sl. Cell Rep. 2015 Nov 3;13(5):898-905. doi: 10.1016/j.celrep.2015.09.057. Epub 2015 Oct 22. Cell Rep. 2015. PMID: 26565903 Free PMC article.
Melanoma metastases caught in the AKT.
Kircher DA, Arave RA, Cho JH, Holmen SL. Kircher DA, et al. Among authors: holmen sl. Mol Cell Oncol. 2016 Feb 18;3(2):e1128516. doi: 10.1080/23723556.2015.1128516. eCollection 2016 Mar. Mol Cell Oncol. 2016. PMID: 27308635 Free PMC article.
Melanoma Brain Metastasis: Mechanisms, Models, and Medicine.
Kircher DA, Silvis MR, Cho JH, Holmen SL. Kircher DA, et al. Among authors: holmen sl. Int J Mol Sci. 2016 Sep 2;17(9):1468. doi: 10.3390/ijms17091468. Int J Mol Sci. 2016. PMID: 27598148 Free PMC article. Review.
Resistance mechanisms to genetic suppression of mutant NRAS in melanoma.
Robinson JP, Rebecca VW, Kircher DA, Silvis MR, Smalley I, Gibney GT, Lastwika KJ, Chen G, Davies MA, Grossman D, Smalley KSM, Holmen SL, VanBrocklin MW. Robinson JP, et al. Among authors: holmen sl. Melanoma Res. 2017 Dec;27(6):545-557. doi: 10.1097/CMR.0000000000000403. Melanoma Res. 2017. PMID: 29076949 Free PMC article.
AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis.
Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen SL. Kircher DA, et al. Among authors: holmen sl. Mol Cancer Res. 2019 Sep;17(9):1787-1800. doi: 10.1158/1541-7786.MCR-18-1372. Epub 2019 May 28. Mol Cancer Res. 2019. PMID: 31138602 Free PMC article.
65 results