Model-dependent outcomes: Sex as a biological variable in preclinical mouse models of melanoma

Pigment Cell Melanoma Res. 2021 May;34(3):655-658. doi: 10.1111/pcmr.12940. Epub 2020 Nov 11.

Authors

Gennie L Parkman^{1

2}, David A Kircher^{2

3}, Christopher M Stehn², Martin McMahon^{1

2

4}, Sheri L Holmen^{1

2

3}

Affiliations

¹ Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
² Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
³ Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
⁴ Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT, USA.

No abstract available

Keywords: melanoma; mouse models; sex as a biological variable.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Humans
Melanoma / etiology
Melanoma / metabolism
Melanoma / pathology*
Mice
Mice, Knockout
PTEN Phosphohydrolase / physiology*
Proto-Oncogene Proteins B-raf / physiology*
Sex Factors

Substances

Braf protein, mouse
Proto-Oncogene Proteins B-raf
PTEN Phosphohydrolase
Pten protein, mouse

Grants and funding