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The Nijmegen ultra-sensitive Bethesda Assay detects very low-titer factor VIII inhibitors in patients with congenital and acquired hemophilia A.
Valke LLFG, Verhagen MJA, Mulders BTPM, Polenewen R, Blijlevens NMA, Jansen JH, Mansouritorghabeh H, Elsheikh E, Reipert BM, Turecek PL, O'Donnell JS, Rijpma SR, Schols SEM, van Heerde WL, Meijer D. Valke LLFG, et al. Among authors: verhagen mja. Thromb Res. 2023 Nov;231:112-120. doi: 10.1016/j.thromres.2023.10.007. Epub 2023 Oct 11. Thromb Res. 2023. PMID: 37844518
In patients with hemophilia, a decreased thrombin generation profile is associated with a severe bleeding phenotype.
Verhagen MJA, van Heerde WL, van der Bom JG, Beckers EAM, Blijlevens NMA, Coppens M, Gouw SC, Jansen JH, Leebeek FWG, van Vulpen LFD, Meijer D, Schols SEM. Verhagen MJA, et al. Res Pract Thromb Haemost. 2023 Feb 1;7(2):100062. doi: 10.1016/j.rpth.2023.100062. eCollection 2023 Feb. Res Pract Thromb Haemost. 2023. PMID: 36865907 Free PMC article.
The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A.
Oomen I, Verhagen M, Miranda M, Allacher P, Beckers EAM, Blijlevens NMA, van der Bom JG, Coppens M, Driessens M, Eikenboom JCJ, Fijnvandraat K, Hassan S, van Heerde WL, Hooimeijer HL, Jansen JH, Kaijen P, Leebeek FWG, Meijer D, Paul H, Rijpma SR, Rosendaal FR, Smit C, van Vulpen LFD, Voorberg J, Schols SEM, Gouw SC. Oomen I, et al. Front Immunol. 2024 Feb 22;15:1355813. doi: 10.3389/fimmu.2024.1355813. eCollection 2024. Front Immunol. 2024. PMID: 38455035 Free PMC article.