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A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Among authors: barbosa bcm. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145
RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice.
Costa SOAM, Rodrigues IB, Braga AV, Barbosa BCM, Silva RRL, Rodrigues FF, Melo ISF, Morais MÍ, Castro BFM, Júnior ASC, Maltarollo VG, Oliveira RB, Coelho MM, Machado RR. Costa SOAM, et al. Among authors: barbosa bcm. Inflammopharmacology. 2022 Apr;30(2):505-515. doi: 10.1007/s10787-021-00913-9. Epub 2022 Jan 30. Inflammopharmacology. 2022. PMID: 35094257
Synthesis of 2-(2-(4-thioxo-3H-1,2-dithiole-5-yl) phenoxy)ethyl)isoindole-1,3-thione, a novel hydrogen sulfide-releasing phthalimide hybrid, and evaluation of its activity in models of inflammatory pain.
Melo ISF, Ziviani VP, Barbosa BCM, Rodrigues FF, Silva RRL, da Silva Neto L, de Fátima Â, César IC, Machado RR, Coelho MM. Melo ISF, et al. Among authors: barbosa bcm. Eur J Pharmacol. 2023 Jan 5;938:175409. doi: 10.1016/j.ejphar.2022.175409. Epub 2022 Nov 25. Eur J Pharmacol. 2023. PMID: 36436591
Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus.
Morais MÍ, Braga AV, Silva RRL, Barbosa BCM, Costa SOAM, Rodrigues FF, Melo ISF, Matos RC, Carobin NV, Sabino AP, Coelho MM, Machado RR. Morais MÍ, et al. Among authors: barbosa bcm. Cytokine. 2024 Feb;174:156468. doi: 10.1016/j.cyto.2023.156468. Epub 2023 Dec 14. Cytokine. 2024. PMID: 38101167