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Polo-like kinase-1, Aurora kinase A and WEE1 kinase are promising druggable targets in CML cells displaying BCR::ABL1-independent resistance to tyrosine kinase inhibitors.
Mancini M, De Santis S, Monaldi C, Castagnetti F, Lonetti A, Bruno S, Dan E, Sinigaglia B, Rosti G, Cavo M, Gugliotta G, Soverini S. Mancini M, et al. Among authors: monaldi c. Front Oncol. 2022 Aug 5;12:901132. doi: 10.3389/fonc.2022.901132. eCollection 2022. Front Oncol. 2022. PMID: 35992847 Free PMC article.
Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors.
Mancini M, De Santis S, Monaldi C, Bavaro L, Martelli M, Castagnetti F, Gugliotta G, Rosti G, Santucci MA, Martinelli G, Cavo M, Soverini S. Mancini M, et al. Among authors: monaldi c. J Exp Clin Cancer Res. 2019 May 23;38(1):216. doi: 10.1186/s13046-019-1197-9. J Exp Clin Cancer Res. 2019. PMID: 31122263 Free PMC article.
Case Report: A Novel Activating FLT3 Mutation in Acute Myeloid Leukemia.
Bruno S, Bandini L, Patuelli A, Robustelli V, Venturi C, Mancini M, Forte D, De Santis S, Monaldi C, Grassi A, Chiurumbolo G, Paolini S, Cristiano G, Papayannidis C, Sartor C, Nanni J, Ottaviani E, Curti A, Cavo M, Soverini S. Bruno S, et al. Among authors: monaldi c. Front Oncol. 2021 Sep 30;11:728613. doi: 10.3389/fonc.2021.728613. eCollection 2021. Front Oncol. 2021. PMID: 34660293 Free PMC article.
Droplet digital PCR for the detection of second-generation tyrosine kinase inhibitor-resistant BCR::ABL1 kinase domain mutations in chronic myeloid leukemia.
Soverini S, De Santis S, Martelli M, Monaldi C, Castagnetti F, Gugliotta G, Papayannidis C, Mancini M, Bruno S, Venturi C, Machova Polakova K, Ernst T, Maar D, Corner A, Cavo M. Soverini S, et al. Among authors: monaldi c. Leukemia. 2022 Sep;36(9):2250-2260. doi: 10.1038/s41375-022-01660-8. Epub 2022 Jul 30. Leukemia. 2022. PMID: 35908105
17 results