Ponatinib treatment in chronic myeloid leukemia cell lines targets aurora kinase A/FOXM1 axis

MeSH terms

• Apoptosis / drug effects*
• Aurora Kinase A / genetics
• Aurora Kinase A / metabolism*
• Cell Proliferation / drug effects
• Drug Resistance, Neoplasm*
• Forkhead Box Protein M1 / genetics
• Forkhead Box Protein M1 / metabolism*
• Gene Expression Regulation, Neoplastic / drug effects*
• Humans
• Imidazoles / pharmacology*
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
• Protein Kinase Inhibitors / pharmacology
• Pyridazines / pharmacology*
• Tumor Cells, Cultured