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Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
Richardson BG, Jain AD, Speltz TE, Moore TW. Richardson BG, et al. Among authors: moore tw. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2261-8. doi: 10.1016/j.bmcl.2015.04.019. Epub 2015 Apr 16. Bioorg Med Chem Lett. 2015. PMID: 25937010 Free PMC article. Review.
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
Richardson BG, Jain AD, Potteti HR, Lazzara PR, David BP, Tamatam CR, Choma E, Skowron K, Dye K, Siddiqui Z, Wang YT, Krunic A, Reddy SP, Moore TW. Richardson BG, et al. Among authors: moore tw. J Med Chem. 2018 Sep 13;61(17):8029-8047. doi: 10.1021/acs.jmedchem.8b01133. Epub 2018 Aug 31. J Med Chem. 2018. PMID: 30122040 Free PMC article.
Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.
Lazzara PR, Jain AD, Maldonado AC, Richardson B, Skowron KJ, David BP, Siddiqui Z, Ratia KM, Moore TW. Lazzara PR, et al. Among authors: moore tw. ACS Med Chem Lett. 2020 Feb 19;11(4):521-527. doi: 10.1021/acsmedchemlett.9b00631. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292559 Free PMC article.
Synthesis, Optimization, and Structure-Activity Relationships of Imidazo[1,2-a]pyrimidines as Inhibitors of Group 2 Influenza A Viruses.
Alqarni S, Cooper L, Galvan Achi J, Bott R, Sali VK, Brown A, Santarsiero BD, Krunic A, Manicassamy B, Peet NP, Zhang P, Thatcher GRJ, Gaisina IN, Rong L, Moore TW. Alqarni S, et al. Among authors: moore tw. J Med Chem. 2022 Oct 27;65(20):14104-14120. doi: 10.1021/acs.jmedchem.2c01329. Epub 2022 Oct 19. J Med Chem. 2022. PMID: 36260129
Structure-Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin.
Skowron KJ, Baliga C, Johnson T, Kremiller KM, Castroverde A, Dean TT, Allen AC, Lopez-Hernandez AM, Aleksandrova EV, Klepacki D, Mankin AS, Polikanov YS, Moore TW. Skowron KJ, et al. Among authors: moore tw. J Med Chem. 2023 Sep 14;66(17):11831-11842. doi: 10.1021/acs.jmedchem.3c00406. Epub 2023 Aug 21. J Med Chem. 2023. PMID: 37603874 Free PMC article.
98 results