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Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning.
Mueller YM, Schrama TJ, Ruijten R, Schreurs MWJ, Grashof DGB, van de Werken HJG, Lasinio GJ, Álvarez-Sierra D, Kiernan CH, Castro Eiro MD, van Meurs M, Brouwers-Haspels I, Zhao M, Li L, de Wit H, Ouzounis CA, Wilmsen MEP, Alofs TM, Laport DA, van Wees T, Kraker G, Jaimes MC, Van Bockstael S, Hernández-González M, Rokx C, Rijnders BJA, Pujol-Borrell R, Katsikis PD. Mueller YM, et al. Among authors: brouwers haspels i. Nat Commun. 2022 Feb 17;13(1):915. doi: 10.1038/s41467-022-28621-0. Nat Commun. 2022. PMID: 35177626 Free PMC article.
The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.
Hope JL, Stairiker CJ, Spantidea PI, Gracias DT, Carey AJ, Fike AJ, van Meurs M, Brouwers-Haspels I, Rijsbergen LC, Fraietta JA, Mueller YM, Klop RC, Stelekati E, Wherry EJ, Erkeland SJ, Katsikis PD. Hope JL, et al. Among authors: brouwers haspels i. Front Immunol. 2017 Dec 6;8:1696. doi: 10.3389/fimmu.2017.01696. eCollection 2017. Front Immunol. 2017. PMID: 29358931 Free PMC article.
Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.
Zhao M, Kiernan CH, Stairiker CJ, Hope JL, Leon LG, van Meurs M, Brouwers-Haspels I, Boers R, Boers J, Gribnau J, van IJcken WFJ, Bindels EM, Hoogenboezem RM, Erkeland SJ, Mueller YM, Katsikis PD. Zhao M, et al. Among authors: brouwers haspels i. PLoS Pathog. 2020 Jun 24;16(6):e1008555. doi: 10.1371/journal.ppat.1008555. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32579593 Free PMC article.
MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses.
Hope JL, Zhao M, Stairiker CJ, Kiernan CH, Carey AJ, Mueller YM, van Meurs M, Brouwers-Haspels I, Otero DC, Bae EA, Faso HA, Maas A, de Looper H, Fortina PM, Rigoutsos I, Bradley LM, Erkeland SJ, Katsikis PD. Hope JL, et al. Among authors: brouwers haspels i. J Immunol. 2022 Feb 1;208(3):603-617. doi: 10.4049/jimmunol.2000621. Epub 2022 Jan 12. J Immunol. 2022. PMID: 35022277 Free PMC article.
Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK.
Li L, Zhao M, Kiernan CH, Castro Eiro MD, van Meurs M, Brouwers-Haspels I, Wilmsen MEP, Grashof DGB, van de Werken HJG, Hendriks RW, Mueller YM, Katsikis PD. Li L, et al. Among authors: brouwers haspels i. Front Immunol. 2023 Sep 12;14:1201415. doi: 10.3389/fimmu.2023.1201415. eCollection 2023. Front Immunol. 2023. PMID: 37771591 Free PMC article.
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