Houk KN - Search Results

1

Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold.

Basler S, Studer S, Zou Y, Mori T, Ota Y, Camus A, Bunzel HA, Helgeson RC, Houk KN, Jiménez-Osés G, Hilvert D. Basler S, et al. Among authors: houk kn. Nat Chem. 2021 Mar;13(3):231-235. doi: 10.1038/s41557-020-00628-4. Epub 2021 Feb 1. Nat Chem. 2021. PMID: 33526894

2

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.

Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA. Xu J, et al. Among authors: houk kn. Science. 1999 Dec 17;286(5448):2345-8. doi: 10.1126/science.286.5448.2345. Science. 1999. PMID: 10600746

3

Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.

Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA. Hotta K, et al. Among authors: houk kn. J Mol Biol. 2000 Oct 6;302(5):1213-25. doi: 10.1006/jmbi.2000.4503. J Mol Biol. 2000. PMID: 11183784

4

Shape complementarity, binding-site dynamics, and transition state stabilization: a theoretical study of Diels-Alder catalysis by antibody 1E9.

Chen J, Deng Q, Wang R, Houk K, Hilvert D. Chen J, et al. Chembiochem. 2000 Nov 17;1(4):255-61. doi: 10.1002/1439-7633(20001117)1:4<255::AID-CBIC255>3.0.CO;2-S. Chembiochem. 2000. PMID: 11828417

5

The origins of noncovalent catalysis of intermolecular Diels-Alder reactions by cyclodextrins, self-assembling capsules, antibodies, and RNAses.

Kim SP, Leach AG, Houk KN. Kim SP, et al. Among authors: houk kn. J Org Chem. 2002 Jun 14;67(12):4250-60. doi: 10.1021/jo011180d. J Org Chem. 2002. PMID: 12054961

6

Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole.

Ujaque G, Tantillo DJ, Hu Y, Houk KN, Hotta K, Hilvert D. Ujaque G, et al. Among authors: houk kn. J Comput Chem. 2003 Jan 15;24(1):98-110. doi: 10.1002/jcc.10151. J Comput Chem. 2003. PMID: 12483679

7

Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles.

Hu Y, Houk KN, Kikuchi K, Hotta K, Hilvert D. Hu Y, et al. Among authors: houk kn. J Am Chem Soc. 2004 Jul 7;126(26):8197-205. doi: 10.1021/ja0490727. J Am Chem Soc. 2004. PMID: 15225061

8

Acid/base catalysis by pure water: the aldol reaction.

Zhang X, Houk KN. Zhang X, et al. Among authors: houk kn. J Org Chem. 2005 Nov 25;70(24):9712-6. doi: 10.1021/jo0509455. J Org Chem. 2005. PMID: 16292798

9

De novo computational design of retro-aldol enzymes.

Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF 3rd, Hilvert D, Houk KN, Stoddard BL, Baker D. Jiang L, et al. Among authors: houk kn. Science. 2008 Mar 7;319(5868):1387-91. doi: 10.1126/science.1152692. Science. 2008. PMID: 18323453 Free PMC article.

10

Kemp elimination catalysts by computational enzyme design.

Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Röthlisberger D, et al. Among authors: houk kn. Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19. Nature. 2008. PMID: 18354394

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