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Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies.
Poulsen ET, Runager K, Nielsen NS, Lukassen MV, Thomsen K, Snider P, Simmons O, Vorum H, Conway SJ, Enghild JJ. Poulsen ET, et al. Among authors: nielsen ns. FEBS J. 2018 Jan;285(1):101-114. doi: 10.1111/febs.14321. Epub 2017 Nov 23. FEBS J. 2018. PMID: 29117645 Free PMC article.
The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation.
Poulsen ET, Nielsen NS, Scavenius C, Mogensen EH, Risør MW, Runager K, Lukassen MV, Rasmussen CB, Christiansen G, Richner M, Vorum H, Enghild JJ. Poulsen ET, et al. Among authors: nielsen ns. J Biol Chem. 2019 Aug 2;294(31):11817-11828. doi: 10.1074/jbc.RA119.009050. Epub 2019 Jun 13. J Biol Chem. 2019. PMID: 31197037 Free PMC article.
Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies.
Nielsen NS, Poulsen ET, Lukassen MV, Chao Shern C, Mogensen EH, Weberskov CE, DeDionisio L, Schauser L, Moore TCB, Otzen DE, Hjortdal J, Enghild JJ. Nielsen NS, et al. Prog Retin Eye Res. 2020 Jul;77:100843. doi: 10.1016/j.preteyeres.2020.100843. Epub 2020 Jan 29. Prog Retin Eye Res. 2020. PMID: 32004730 Review.
62 results