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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20.
Nat Rev Drug Discov. 2020.
PMID: 31748707
Free article.
Review.
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.
Dragovic S, Vermeulen NP, Gerets HH, Hewitt PG, Ingelman-Sundberg M, Park BK, Juhila S, Snoeys J, Weaver RJ.
Dragovic S, et al. Among authors: juhila s.
Arch Toxicol. 2016 Dec;90(12):2979-3003. doi: 10.1007/s00204-016-1845-1. Epub 2016 Sep 22.
Arch Toxicol. 2016.
PMID: 27659300
Free PMC article.
Review.
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Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK.
Goldring C, et al. Among authors: juhila s.
Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30.
Hepatology. 2017.
PMID: 27775817
Free PMC article.
Review.
Item in Clipboard
Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.
Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK.
Weaver RJ, et al. Among authors: juhila s.
Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):767-782. doi: 10.1080/17425255.2017.1341489. Epub 2017 Jun 28.
Expert Opin Drug Metab Toxicol. 2017.
PMID: 28604124
Review.
Item in Clipboard
Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.
Richert L, Baze A, Parmentier C, Gerets HHJ, Sison-Young R, Dorau M, Lovatt C, Czich A, Goldring C, Park BK, Juhila S, Foster AJ, Williams DP.
Richert L, et al. Among authors: juhila s.
Toxicol Lett. 2016 Sep 6;258:207-215. doi: 10.1016/j.toxlet.2016.06.1127. Epub 2016 Jun 27.
Toxicol Lett. 2016.
PMID: 27363785
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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Bell CC, Dankers ACA, Lauschke VM, Sison-Young R, Jenkins R, Rowe C, Goldring CE, Park K, Regan SL, Walker T, Schofield C, Baze A, Foster AJ, Williams DP, van de Ven AWM, Jacobs F, Houdt JV, Lähteenmäki T, Snoeys J, Juhila S, Richert L, Ingelman-Sundberg M.
Bell CC, et al. Among authors: juhila s.
Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289.
Toxicol Sci. 2018.
PMID: 29329425
Free PMC article.
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2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists.
Wang S, Haikarainen A, Pohjakallio A, Sipilä J, Kaskinoro J, Juhila S, Jalava N, Koskinen M, Vesajoki M, Kumpulainen E, Pystynen J, Koskelainen T, Holm P, Din Belle D.
Wang S, et al. Among authors: juhila s.
Bioorg Med Chem Lett. 2022 Aug 1;69:128783. doi: 10.1016/j.bmcl.2022.128783. Epub 2022 May 13.
Bioorg Med Chem Lett. 2022.
PMID: 35569686
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Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists.
Wang S, Haikarainen A, Pohjakallio A, Sipilä J, Kaskinoro J, Juhila S, Jalava N, Koskinen M, Vesajoki M, Kumpulainen E, Pystynen J, Koskelainen T, Holm P, Din Belle D.
Wang S, et al. Among authors: juhila s.
Bioorg Med Chem Lett. 2022 Dec 1;77:129005. doi: 10.1016/j.bmcl.2022.129005. Epub 2022 Sep 26.
Bioorg Med Chem Lett. 2022.
PMID: 36174834
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