Matthews JM - Search Results

1

Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

Brooks CA, Barton LS, Behm DJ, Brnardic EJ, Costell MH, Holt DA, Jolivette LJ, Matthews JM, McAtee JJ, McCleland BW, Patterson JR, Pero JE, Rivero RA, Roethke TJ, Sanchez RM, Shenje R, Terrell LR, Lawhorn BG. Brooks CA, et al. Among authors: matthews jm. J Med Chem. 2019 Oct 24;62(20):9270-9280. doi: 10.1021/acs.jmedchem.9b01247. Epub 2019 Oct 9. J Med Chem. 2019. PMID: 31532662

2

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

Pero JE, Matthews JM, Behm DJ, Brnardic EJ, Brooks C, Budzik BW, Costell MH, Donatelli CA, Eisennagel SH, Erhard K, Fischer MC, Holt DA, Jolivette LJ, Li H, Li P, McAtee JJ, McCleland BW, Pendrak I, Posobiec LM, Rivera KLK, Rivero RA, Roethke TJ, Sender MR, Shu A, Terrell LR, Vaidya K, Xu X, Lawhorn BG. Pero JE, et al. Among authors: matthews jm. J Med Chem. 2018 Dec 27;61(24):11209-11220. doi: 10.1021/acs.jmedchem.8b01344. Epub 2018 Dec 12. J Med Chem. 2018. PMID: 30500190

3

Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators.

Glogowski MP, Matthews JM, Lawhorn BG, Minbiole KPC. Glogowski MP, et al. Among authors: matthews jm. J Org Chem. 2021 Feb 19;86(4):3120-3137. doi: 10.1021/acs.joc.0c02639. Epub 2021 Feb 8. J Org Chem. 2021. PMID: 33555189

4

Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.

Matthews JM, Liotta F, Hageman W, Rivero RA, Westover L, Yang M, Xu J, Demarest K. Matthews JM, et al. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1155-9. doi: 10.1016/j.bmcl.2003.12.071. Bioorg Med Chem Lett. 2004. PMID: 14980655

5

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Matthews JM, Qin N, Colburn RW, Dax SL, Hawkins M, McNally JJ, Reany L, Youngman MA, Baker J, Hutchinson T, Liu Y, Lubin ML, Neeper M, Brandt MR, Stone DJ, Flores CM. Matthews JM, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2922-6. doi: 10.1016/j.bmcl.2012.02.060. Epub 2012 Feb 27. Bioorg Med Chem Lett. 2012. PMID: 22421018

6

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.

Zhu B, Xia M, Xu X, Ludovici DW, Tennakoon M, Youngman MA, Matthews JM, Dax SL, Colburn RW, Qin N, Hutchinson TL, Lubin ML, Brandt MR, Stone DJ, Flores CM, Macielag MJ. Zhu B, et al. Among authors: matthews jm. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2234-7. doi: 10.1016/j.bmcl.2013.01.062. Epub 2013 Feb 4. Bioorg Med Chem Lett. 2013. PMID: 23411075

7

Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.

Matthews JM, Hoekstra WJ, Dyatkin AB, Hecker LR, Hlasta DJ, Poulter BL, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Reynolds CH, Maryanoff BE. Matthews JM, et al. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2747-52. doi: 10.1016/j.bmcl.2004.03.083. Bioorg Med Chem Lett. 2004. PMID: 15125926

8

Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.

Matthews JM, Greco MN, Hecker LR, Hoekstra WJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Maryanoff BE. Matthews JM, et al. Bioorg Med Chem Lett. 2003 Feb 24;13(4):753-6. doi: 10.1016/s0960-894x(02)01059-4. Bioorg Med Chem Lett. 2003. PMID: 12639574

9

Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.

Matthews JM, Chen X, Cryan E, Hlasta DJ, Rybczynski PJ, Strauss K, Tang Y, Xu JZ, Yang M, Zhou L, Demarest KT. Matthews JM, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6773-8. doi: 10.1016/j.bmcl.2007.10.041. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029176

10

Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.

Zhu B, Matthews JM, Xia M, Black S, Chen C, Hou C, Liang Y, Tang Y, Macielag MJ. Zhu B, et al. Among authors: matthews jm. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5597-5601. doi: 10.1016/j.bmcl.2016.09.026. Epub 2016 Sep 12. Bioorg Med Chem Lett. 2016. PMID: 27671499

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