Santamaria S - Search Results

1

Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis.

Santamaria S, Yamamoto K, Teraz-Orosz A, Koch C, Apte SS, de Groot R, Lane DA, Ahnström J. Santamaria S, et al. Sci Rep. 2019 Jul 29;9(1):10914. doi: 10.1038/s41598-019-47494-w. Sci Rep. 2019. PMID: 31358852 Free PMC article.

2

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

Nuti E, Santamaria S, Casalini F, Yamamoto K, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Marini AM, Salerno S, Taliani S, Da Settimo F, Nagase H, Rossello A. Nuti E, et al. Among authors: santamaria s. Eur J Med Chem. 2013 Apr;62:379-94. doi: 10.1016/j.ejmech.2012.12.058. Epub 2013 Jan 11. Eur J Med Chem. 2013. PMID: 23376997

3

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).

Santamaria S, Yamamoto K, Botkjaer K, Tape C, Dyson MR, McCafferty J, Murphy G, Nagase H. Santamaria S, et al. Biochem J. 2015 Nov 1;471(3):391-401. doi: 10.1042/BJ20150758. Epub 2015 Aug 24. Biochem J. 2015. PMID: 26303525 Free PMC article.

4

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S, Dudhia J, Troeberg L, Strickland DK, Hirohata S, Nagase H. Yamamoto K, et al. Among authors: santamaria s. Matrix Biol. 2016 Dec;56:57-73. doi: 10.1016/j.matbio.2016.03.007. Epub 2016 Apr 12. Matrix Biol. 2016. PMID: 27084377 Free PMC article.

5

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

Yamamoto K, Santamaria S, Botkjaer KA, Dudhia J, Troeberg L, Itoh Y, Murphy G, Nagase H. Yamamoto K, et al. Among authors: santamaria s. Arthritis Rheumatol. 2017 Jun;69(6):1246-1256. doi: 10.1002/art.40080. Epub 2017 Apr 28. Arthritis Rheumatol. 2017. PMID: 28235248 Free PMC article.

6

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

Santamaria S, Fedorov O, McCafferty J, Murphy G, Dudhia J, Nagase H, Yamamoto K. Santamaria S, et al. MAbs. 2017 May/Jun;9(4):595-602. doi: 10.1080/19420862.2017.1304341. Epub 2017 Mar 17. MAbs. 2017. PMID: 28306378 Free PMC article.

7

Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation.

Santamaria S, Reglińska-Matveyev N, Gierula M, Camire RM, Crawley JTB, Lane DA, Ahnström J. Santamaria S, et al. J Biol Chem. 2017 Jun 2;292(22):9335-9344. doi: 10.1074/jbc.M116.769570. Epub 2017 Apr 18. J Biol Chem. 2017. PMID: 28420729 Free PMC article.

8

Monoclonal antibodies against metzincin targets.

Santamaria S, de Groot R. Santamaria S, et al. Br J Pharmacol. 2019 Jan;176(1):52-66. doi: 10.1111/bph.14186. Epub 2018 Apr 2. Br J Pharmacol. 2019. PMID: 29488211 Free PMC article. Review.

9

Proteomic discovery of substrates of the cardiovascular protease ADAMTS7.

Colige A, Monseur C, Crawley JTB, Santamaria S, de Groot R. Colige A, et al. Among authors: santamaria s. J Biol Chem. 2019 May 17;294(20):8037-8045. doi: 10.1074/jbc.RA119.007492. Epub 2019 Mar 29. J Biol Chem. 2019. PMID: 30926607 Free PMC article.

10

The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex.

Gierula M, Salles-Crawley II, Santamaria S, Teraz-Orosz A, Crawley JTB, Lane DA, Ahnström J. Gierula M, et al. Among authors: santamaria s. J Thromb Haemost. 2019 Dec;17(12):2056-2068. doi: 10.1111/jth.14594. Epub 2019 Aug 9. J Thromb Haemost. 2019. PMID: 31364267 Free PMC article.

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