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Page 1
In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab-MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios.
Bryant P, Pabst M, Badescu G, Bird M, McDowell W, Jamieson E, Swierkosz J, Jurlewicz K, Tommasi R, Henseleit K, Sheng X, Camper N, Manin A, Kozakowska K, Peciak K, Laurine E, Grygorash R, Kyle A, Morris D, Parekh V, Abhilash A, Choi JW, Edwards J, Frigerio M, Baker MP, Godwin A. Bryant P, et al. Among authors: bird m. Mol Pharm. 2015 Jun 1;12(6):1872-9. doi: 10.1021/acs.molpharmaceut.5b00116. Epub 2015 May 5. Mol Pharm. 2015. PMID: 25894424
Bridging disulfides for stable and defined antibody drug conjugates.
Badescu G, Bryant P, Bird M, Henseleit K, Swierkosz J, Parekh V, Tommasi R, Pawlisz E, Jurlewicz K, Farys M, Camper N, Sheng X, Fisher M, Grygorash R, Kyle A, Abhilash A, Frigerio M, Edwards J, Godwin A. Badescu G, et al. Among authors: bird m. Bioconjug Chem. 2014 Jun 18;25(6):1124-36. doi: 10.1021/bc500148x. Epub 2014 May 23. Bioconjug Chem. 2014. PMID: 24791606
Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates.
Pabst M, McDowell W, Manin A, Kyle A, Camper N, De Juan E, Parekh V, Rudge F, Makwana H, Kantner T, Parekh H, Michelet A, Sheng X, Popa G, Tucker C, Khayrzad F, Pollard D, Kozakowska K, Resende R, Jenkins A, Simoes F, Morris D, Williams P, Badescu G, Baker MP, Bird M, Frigerio M, Godwin A. Pabst M, et al. Among authors: bird m. J Control Release. 2017 May 10;253:160-164. doi: 10.1016/j.jconrel.2017.02.027. Epub 2017 Mar 1. J Control Release. 2017. PMID: 28257988
Bridged Cysteine Conjugations.
Bird M, Nunes J, Frigerio M. Bird M, et al. Methods Mol Biol. 2020;2078:113-129. doi: 10.1007/978-1-4939-9929-3_8. Methods Mol Biol. 2020. PMID: 31643053
Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance.
Evans N, Grygorash R, Williams P, Kyle A, Kantner T, Pathak R, Sheng X, Simoes F, Makwana H, Resende R, de Juan E, Jenkins A, Morris D, Michelet A, Jewitt F, Rudge F, Camper N, Manin A, McDowell W, Pabst M, Godwin A, Frigerio M, Bird M. Evans N, et al. Among authors: bird m. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022. Front Pharmacol. 2022. PMID: 35784686 Free PMC article.
Site-specific PEGylation at histidine tags.
Cong Y, Pawlisz E, Bryant P, Balan S, Laurine E, Tommasi R, Singh R, Dubey S, Peciak K, Bird M, Sivasankar A, Swierkosz J, Muroni M, Heidelberger S, Farys M, Khayrzad F, Edwards J, Badescu G, Hodgson I, Heise C, Somavarapu S, Liddell J, Powell K, Zloh M, Choi JW, Godwin A, Brocchini S. Cong Y, et al. Among authors: bird m. Bioconjug Chem. 2012 Feb 15;23(2):248-63. doi: 10.1021/bc200530x. Epub 2012 Feb 6. Bioconjug Chem. 2012. PMID: 22243664
Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality.
Cooper CE , Silkstone GGA , Simons M , Gretton S , Rajagopal BS , Allen-Baume V , Syrett N , Shaik T , Popa G , Sheng X , Bird M , Choi JW , Piano R , Ronda L , Bettati S , Paredi G , Mozzarelli A , Reeder BJ . Cooper CE , et al. Among authors: bird m. Biomater Sci. 2020 Jul 21;8(14):3896-3906. doi: 10.1039/c9bm01773a. Epub 2020 Jun 15. Biomater Sci. 2020. PMID: 32539053
Measuring Rates of ATP Synthesis.
Bird MJ, Radenkovic S, Vermeersch P, Cassiman D. Bird MJ, et al. Methods Mol Biol. 2019;1862:97-107. doi: 10.1007/978-1-4939-8769-6_7. Methods Mol Biol. 2019. PMID: 30315462
Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction.
Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B. Adant I, et al. Among authors: bird m. Mol Metab. 2022 Sep;63:101537. doi: 10.1016/j.molmet.2022.101537. Epub 2022 Jun 27. Mol Metab. 2022. PMID: 35772644 Free PMC article.
717 results