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Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Agelis G, Resvani A, Koukoulitsa C, Tůmová T, Slaninová J, Kalavrizioti D, Spyridaki K, Afantitis A, Melagraki G, Siafaka A, Gkini E, Megariotis G, Grdadolnik SG, Papadopoulos MG, Vlahakos D, Maragoudakis M, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: vlahakos d. Eur J Med Chem. 2013 Apr;62:352-70. doi: 10.1016/j.ejmech.2012.12.044. Epub 2013 Jan 2. Eur J Med Chem. 2013. PMID: 23376252 Free article.
Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Roumelioti P, Polevaya L, Zoumpoulakis P, Giatas N, Mutule I, Keivish T, Zoga A, Vlahakos D, Iliodromitis E, Kremastinos D, Grdadolnik SG, Mavromoustakos T, Matsoukas J. Roumelioti P, et al. Among authors: vlahakos d. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2627-33. doi: 10.1016/s0960-894x(02)00474-2. Bioorg Med Chem Lett. 2002. PMID: 12182875
An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT(1) angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies.
Agelis G, Roumelioti P, Resvani A, Durdagi S, Androutsou ME, Kelaidonis K, Vlahakos D, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: vlahakos d. J Comput Aided Mol Des. 2010 Sep;24(9):749-58. doi: 10.1007/s10822-010-9371-3. Epub 2010 Jul 10. J Comput Aided Mol Des. 2010. PMID: 20623162
The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.
Agelis G, Resvani A, Durdagi S, Spyridaki K, Tůmová T, Slaninová J, Giannopoulos P, Vlahakos D, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: vlahakos d. Eur J Med Chem. 2012 Sep;55:358-74. doi: 10.1016/j.ejmech.2012.07.040. Epub 2012 Jul 31. Eur J Med Chem. 2012. PMID: 22889560
Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers.
Agelis G, Kelaidonis K, Resvani A, Kalavrizioti D, Androutsou ME, Plotas P, Vlahakos D, Koukoulitsa C, Tselios T, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: vlahakos d. Molecules. 2013 Jun 27;18(7):7510-32. doi: 10.3390/molecules18077510. Molecules. 2013. PMID: 23807577 Free PMC article.
Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities.
Alexopoulos K, Fatseas P, Melissari E, Vlahakos D, Roumelioti P, Mavromoustakos T, Mihailescu S, Paredes-Carbajal MC, Mascher D, Matsoukas J. Alexopoulos K, et al. Among authors: vlahakos d. J Med Chem. 2004 Jun 17;47(13):3338-52. doi: 10.1021/jm031080v. J Med Chem. 2004. PMID: 15189031
Conformation and bioactivity. Design and discovery of novel antihypertensive drugs.
Mavromoustakos T, Zervou M, Zoumpoulakis P, Kyrikou I, Benetis NP, Polevaya L, Roumelioti P, Giatas N, Zoga A, Minakakis PM, Kolocouris A, Vlahakos D, Grdadolnik SG, Matsoukas J. Mavromoustakos T, et al. Among authors: vlahakos d. Curr Top Med Chem. 2004;4(4):385-401. doi: 10.2174/1568026043451302. Curr Top Med Chem. 2004. PMID: 14965308 Review.
85 results