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SAR studies of acidic dual γ-secretase/PPARγ modulators.
Hieke M, Ness J, Steri R, Greiner C, Werz O, Schubert-Zsilavecz M, Weggen S, Zettl H. Hieke M, et al. Bioorg Med Chem. 2011 Sep 15;19(18):5372-82. doi: 10.1016/j.bmc.2011.08.003. Epub 2011 Aug 6. Bioorg Med Chem. 2011. PMID: 21873070
Vanillin-derived antiproliferative compounds influence Plk1 activity.
Carrasco-Gomez R, Keppner-Witter S, Hieke M, Lange L, Schneider G, Schubert-Zsilavecz M, Proschak E, Spänkuch B. Carrasco-Gomez R, et al. Among authors: hieke m. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5063-9. doi: 10.1016/j.bmcl.2014.09.015. Epub 2014 Sep 16. Bioorg Med Chem Lett. 2014. PMID: 25304894
Complementary screening techniques yielded fragments that inhibit the phosphatase activity of soluble epoxide hydrolase.
Hahn S, Achenbach J, Buscató E, Klingler FM, Schroeder M, Meirer K, Hieke M, Heering J, Barbosa-Sicard E, Loehr F, Fleming I, Doetsch V, Schubert-Zsilavecz M, Steinhilber D, Proschak E. Hahn S, et al. Among authors: hieke m. ChemMedChem. 2011 Dec 9;6(12):2146-9. doi: 10.1002/cmdc.201100433. Epub 2011 Oct 21. ChemMedChem. 2011. PMID: 22021219 No abstract available.
[GPCR--structure of the human beta-2 receptor clarified].
Hieke M, Zettl H, Schubert-Zsilavecz M. Hieke M, et al. Pharm Unserer Zeit. 2008;37(3):191-2. doi: 10.1002/pauz.200890028. Pharm Unserer Zeit. 2008. PMID: 18446898 German. No abstract available.
Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R. Choy MS, et al. Among authors: hieke m. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4097-102. doi: 10.1073/pnas.1317395111. Epub 2014 Mar 3. Proc Natl Acad Sci U S A. 2014. PMID: 24591642 Free PMC article.
19 results