Complementary screening techniques yielded fragments that inhibit the phosphatase activity of soluble epoxide hydrolase

ChemMedChem. 2011 Dec 9;6(12):2146-9. doi: 10.1002/cmdc.201100433. Epub 2011 Oct 21.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Drug Evaluation, Preclinical
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Epoxide Hydrolases / antagonists & inhibitors*
  • Epoxide Hydrolases / metabolism
  • Fluorescent Dyes / chemistry
  • Kinetics
  • Protein Structure, Tertiary
  • Substrate Specificity

Substances

  • Enzyme Inhibitors
  • Fluorescent Dyes
  • Epoxide Hydrolases