Okorokov AL - Search Results

1

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A.

Bochkareva E, Kaustov L, Ayed A, Yi GS, Lu Y, Pineda-Lucena A, Liao JC, Okorokov AL, Milner J, Arrowsmith CH, Bochkarev A. Bochkareva E, et al. Among authors: okorokov al. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15412-7. doi: 10.1073/pnas.0504614102. Epub 2005 Oct 17. Proc Natl Acad Sci U S A. 2005. PMID: 16234232 Free PMC article.

2

Proteolytic cleavage of p53: a model for the activation of p53 in response to DNA damage.

Okorokov AL, Milner J. Okorokov AL, et al. Oncol Res. 1997;9(6-7):267-73. Oncol Res. 1997. PMID: 9406231 Review.

3

An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes.

Okorokov AL, Milner J. Okorokov AL, et al. Mol Cell Biol. 1999 Nov;19(11):7501-10. doi: 10.1128/MCB.19.11.7501. Mol Cell Biol. 1999. PMID: 10523638 Free PMC article.

4

The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.

Okorokov AL, Rubbi CP, Metcalfe S, Milner J. Okorokov AL, et al. Oncogene. 2002 Jan 17;21(3):356-67. doi: 10.1038/sj.onc.1205112. Oncogene. 2002. PMID: 11821948

5

Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.

Okorokov AL, Warnock L, Milner J. Okorokov AL, et al. Carcinogenesis. 2002 Apr;23(4):549-57. doi: 10.1093/carcin/23.4.549. Carcinogenesis. 2002. PMID: 11960905

6

Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53.

Okorokov AL, Ponchel F, Milner J. Okorokov AL, et al. EMBO J. 1997 Oct 1;16(19):6008-17. doi: 10.1093/emboj/16.19.6008. EMBO J. 1997. PMID: 9312058 Free PMC article.

7

The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.

Okorokov AL, Sherman MB, Plisson C, Grinkevich V, Sigmundsson K, Selivanova G, Milner J, Orlova EV. Okorokov AL, et al. EMBO J. 2006 Nov 1;25(21):5191-200. doi: 10.1038/sj.emboj.7601382. Epub 2006 Oct 19. EMBO J. 2006. PMID: 17053786 Free PMC article.

8

Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40 kDa and 35 kDa fragments competent for sequence-specific DNA binding.

Molinari M, Okorokov AL, Milner J. Molinari M, et al. Among authors: okorokov al. Oncogene. 1996 Nov 21;13(10):2077-86. Oncogene. 1996. PMID: 8950974

9

Proteolytic cleavage of p53 mutants in response to mismatched DNA.

Mee T, Okorokov AL, Metcalfe S, Milner J. Mee T, et al. Among authors: okorokov al. Br J Cancer. 1999 Sep;81(2):212-8. doi: 10.1038/sj.bjc.6690679. Br J Cancer. 1999. PMID: 10496344 Free PMC article.

The 35-kDa cleavage product is activated for specific biochemical function(s) and may play a role in the cellular response to DNA damage (Molinari et al (1996) Oncogene 13: 2077-2086; Okorokov et al (1997) EMBO J 16: 6008-6017). ...

The 35-kDa cleavage product is activated for specific biochemical function(s) and may play a role in the cellular response to DNA damage (Mo …

10

Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.

Cowell IG, Okorokov AL, Cutts SA, Padget K, Bell M, Milner J, Austin CA. Cowell IG, et al. Among authors: okorokov al. Exp Cell Res. 2000 Feb 25;255(1):86-94. doi: 10.1006/excr.1999.4772. Exp Cell Res. 2000. PMID: 10666337

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