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Redox-regulated conformational changes in an SH3 domain.
Zimmermann J, Kühne R, Sylvester M, Freund C. Zimmermann J, et al. Among authors: kuhne r. Biochemistry. 2007 Jun 12;46(23):6971-7. doi: 10.1021/bi700437r. Epub 2007 May 19. Biochemistry. 2007. PMID: 17511475
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Opitz R, Müller M, Reuter C, Barone M, Soicke A, Roske Y, Piotukh K, Huy P, Beerbaum M, Wiesner B, Beyermann M, Schmieder P, Freund C, Volkmer R, Oschkinat H, Schmalz HG, Kühne R. Opitz R, et al. Among authors: kuhne r. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5011-6. doi: 10.1073/pnas.1422054112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848013 Free PMC article.
Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands.
Zaminer J, Brockmann C, Huy P, Opitz R, Reuter C, Beyermann M, Freund C, Müller M, Oschkinat H, Kühne R, Schmalz HG. Zaminer J, et al. Among authors: kuhne r. Angew Chem Int Ed Engl. 2010 Sep 17;49(39):7111-5. doi: 10.1002/anie.201001739. Angew Chem Int Ed Engl. 2010. PMID: 20803590 No abstract available.
Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.
Höpner S, Dickhaut K, Hofstätter M, Krämer H, Rückerl D, Söderhäll JA, Gupta S, Marin-Esteban V, Kühne R, Freund C, Jung G, Falk K, Rötzschke O. Höpner S, et al. Among authors: kuhne r. J Biol Chem. 2006 Dec 15;281(50):38535-42. doi: 10.1074/jbc.M606437200. Epub 2006 Sep 27. J Biol Chem. 2006. PMID: 17005558 Free article.
127 results