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Year Number of Results
2002 1
2004 1
2005 4
2006 7
2007 13
2008 28
2009 42
2010 83
2011 175
2012 274
2013 441
2014 589
2015 877
2016 1028
2017 1256
2018 1657
2019 1963
2020 1936
2021 1750
2022 1455
2023 1110
2024 442

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13,292 results

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MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Ma Y, She X, Liu Y, Qin X. Ma Y, et al. Commun Biol. 2024 May 11;7(1):562. doi: 10.1038/s42003-024-06236-z. Commun Biol. 2024. PMID: 38734709
MiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an important role in the treatment of sepsis. ...Here, we show that miR-140-3p targeted Hmgb1. MSCs-exo plus miR-140-3p mimic (Exo) and antibiotic imipenem/cilastatin (ABX) improve survival, wei …
MiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an important role in the treatment of sepsis. ...Here, we sho …
Empagliflozin drives ferroptosis in anoikis-resistant cells by activating miR-128-3p dependent pathway and inhibiting CD98hc in breast cancer.
Nalla LV, Khairnar A. Nalla LV, et al. Free Radic Biol Med. 2024 May 9:S0891-5849(24)00453-2. doi: 10.1016/j.freeradbiomed.2024.05.018. Online ahead of print. Free Radic Biol Med. 2024. PMID: 38734268
A tumour suppressor miRNA, miR-128-3p, is widely involved in various biological processes and has been found to get downregulated in breast cancer patients. ...Given that CD98hc is one of the proteins critical in triggering ferroptosis, we confirmed that miR-128-3p and EMP …
A tumour suppressor miRNA, miR-128-3p, is widely involved in various biological processes and has been found to get downregulated in …
LINC01605 promotes malignant phenotypes of cervical cancer via miR-149-3p/WNT7B axis.
Kong X, Xiong Y, Li L. Kong X, et al. Gene. 2024 May 9:148518. doi: 10.1016/j.gene.2024.148518. Online ahead of print. Gene. 2024. PMID: 38734188
To further investigate the mechanism of action, transfection and investigation were performed using specific siRNA, miRNA mimics, or inhibitors. RESULTS: The expression of LINC01605 exhibited a significant increase in CC cell lines, and this upregulation was associa …
To further investigate the mechanism of action, transfection and investigation were performed using specific siRNA, miRNA mimics …
Extracellular Vesicles in Environmental Toxicological Studies: Association between Urinary Concentrations of Phthalate Metabolites and Exosomal miRNA Expression Profiles.
Cocci P, Bondi D, Santangelo C, Pietrangelo T, Verratti V, Cichelli A, Caprioli G, Nzekoue FK, Nguefang MLK, Sagratini G, Mosconi G, Palermo FA. Cocci P, et al. Int J Mol Sci. 2024 Apr 30;25(9):4876. doi: 10.3390/ijms25094876. Int J Mol Sci. 2024. PMID: 38732095 Free PMC article.
Phthalates are chemical compounds, mainly used as additives in plastics, which are known to induce harmful impacts to the environment and human health due to their ability to act as hormone-mimics. Few studies have been reported on the relationship between human exposure t …
Phthalates are chemical compounds, mainly used as additives in plastics, which are known to induce harmful impacts to the environment and hu …
Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma.
Ramadan F, Saab R, Ghamloush F, Khoueiry R, Herceg Z, Gomez L, Badran B, Clezardin P, Hussein N, Cohen PA, Ghayad SE. Ramadan F, et al. Cancers (Basel). 2024 Apr 25;16(9):1652. doi: 10.3390/cancers16091652. Cancers (Basel). 2024. PMID: 38730605 Free PMC article.
RMS-derived exosomes were previously demonstrated to be enriched with miRNAs, including miR-1246, possibly contributing to disease aggressiveness. ...Treatment of normal fibroblasts with FN-RMS-derived exosomes resulted in a significant uptake of miR-1246 paired with an in …
RMS-derived exosomes were previously demonstrated to be enriched with miRNAs, including miR-1246, possibly contributing to disease ag …
miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.
He H, Wang J, Zhang Y, Wang Y, Liu Y, Li X, Zhang Y, Yang J, Hao X, Wang H, Liu H. He H, et al. Ecotoxicol Environ Saf. 2024 May 9;278:116444. doi: 10.1016/j.ecoenv.2024.116444. Online ahead of print. Ecotoxicol Environ Saf. 2024. PMID: 38728943
Recent studies have found that a large number of lymphatic hyperplasia occurs during the occurrence and development of silicosis. miRNAs play an important role in lymphangiogenesis. However, the regulation and mechanism of miRNAs on lymphangiogenesis in silicosis re …
Recent studies have found that a large number of lymphatic hyperplasia occurs during the occurrence and development of silicosis. miRNAs …
Extracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems.
Schuster M, Braun FK, Chiang DM, Ludwig C, Meng C, Grätz C, Kirchner B, Proescholdt M, Hau P, Steinlein OK, Pfaffl MW, Riemenschneider MJ, Reithmair M. Schuster M, et al. Front Immunol. 2024 Apr 25;15:1388769. doi: 10.3389/fimmu.2024.1388769. eCollection 2024. Front Immunol. 2024. PMID: 38726003 Free PMC article.
In silico analysis of differentially regulated miRNAs was performed to identify mRNA targets and corresponding signaling pathways. ...Differential gene expression analysis further revealed the regulation of twelve miRNAs in 3D tumor organoid cultures (with nine m …
In silico analysis of differentially regulated miRNAs was performed to identify mRNA targets and corresponding signaling pathways. .. …
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells.
Hao Y, Song S, Li T, Zai Q, Ma N, Li Y, Yang L, Xiao P, Xu T, Ji L, Tan J, Ahmed YA, Xiang X, Wang X, Lafdil F, Xie Q, He Y. Hao Y, et al. Int J Biol Sci. 2024 Apr 8;20(7):2422-2439. doi: 10.7150/ijbs.92749. eCollection 2024. Int J Biol Sci. 2024. PMID: 38725842 Free PMC article.
Methods: Carbon tetrachloride (CCl(4)) and bile duct ligation (BDL)-induced experimental liver fibrosis models were used. Hepatic miR-144 expression was analyzed by miRNA in situ hybridization with RNAscope probe. The in vivo effects of silencing or overexpressing miR-144 …
Methods: Carbon tetrachloride (CCl(4)) and bile duct ligation (BDL)-induced experimental liver fibrosis models were used. Hepatic miR-144 ex …
Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis.
Li X, Hu Y, Wu Y, Yang Z, Liu Y, Liu H. Li X, et al. J Zhejiang Univ Sci B. 2024 May 15;25(5):422-437. doi: 10.1631/jzus.B2300077. J Zhejiang Univ Sci B. 2024. PMID: 38725341 Free PMC article.
Let-7a-5p was enriched in hucMSCs-exo, and the inhibitory effect of hucMSCs-exo(let-7a-5p) (mimic) on CVB3-induced ferroptosis was higher than that of hucMSCs-exo(mimic NC) (NC: negative control). ...Meanwhile, the levels of GPX4, solute carrier family 7, member 11 …
Let-7a-5p was enriched in hucMSCs-exo, and the inhibitory effect of hucMSCs-exo(let-7a-5p) (mimic) on CVB3-induced ferroptosis was hi …
The Art of Healing Hearts: Mastering Advanced RNA Therapeutic Techniques to Shape the Evolution of Cardiovascular Medicine in Biomedical Science.
Hou G, Alissa M, Alsuwat MA, Alzahrani KJ, Althobaiti FM, Mujalli HM, Alotaiby MM, Saeed S, Al-Doaiss AA, Anthony S. Hou G, et al. Curr Probl Cardiol. 2024 May 7:102627. doi: 10.1016/j.cpcardiol.2024.102627. Online ahead of print. Curr Probl Cardiol. 2024. PMID: 38723793 Review.
Since the early 2000s, the availability of next-generation sequencing techniques such as microRNAs, circular RNAs, and long non-coding RNAs have been proven as potential therapeutic targets for treating various CVDs. ...These methods include single-cell sequencing techniqu …
Since the early 2000s, the availability of next-generation sequencing techniques such as microRNAs, circular RNAs, and long non-codin …
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