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Year Number of Results
2006 2
2007 5
2008 8
2009 11
2010 36
2011 92
2012 158
2013 252
2014 341
2015 528
2016 611
2017 713
2018 937
2019 1091
2020 1069
2021 853
2022 681
2023 476
2024 192

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7,063 results

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Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice.
Castaño C, Kalko S, Novials A, Párrizas M. Castaño C, et al. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12158-12163. doi: 10.1073/pnas.1808855115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429322 Free PMC article.
Moreover, administration of control exosomes transfected with obesity-associated miRNA mimics strongly induces glucose intolerance in lean mice and results in central obesity and hepatic steatosis. ...Treatment with a specific siRNA targeting Ppara transfe …
Moreover, administration of control exosomes transfected with obesity-associated miRNA mimics strongly induces glucose …
Non-viral transfection methods optimized for miRNA delivery to human dermal fibroblasts.
Kucharski M, Mrowiec P, Białka S, Misiołek H, Misiołek M, Sechman A, Zięba-Przybylska D, Ocłoń E. Kucharski M, et al. Mol Med Rep. 2023 Apr;27(4):89. doi: 10.3892/mmr.2023.12976. Epub 2023 Mar 10. Mol Med Rep. 2023. PMID: 36896782
Fibroblasts are beneficial model cells for in vitro studies and are frequently used in tissue engineering. A number of transfection reagents have been employed to deliver microRNAs (miRNAs/miRs) into cells for genetic manipulation. ...However, these results i …
Fibroblasts are beneficial model cells for in vitro studies and are frequently used in tissue engineering. A number of transfection r …
MicroRNA-122 mimic transfection contributes to apoptosis in HepG2 cells.
Huang H, Zhu Y, Li S. Huang H, et al. Mol Med Rep. 2015 Nov;12(5):6918-24. doi: 10.3892/mmr.2015.4254. Epub 2015 Aug 26. Mol Med Rep. 2015. PMID: 26323254
The apoptotic rates of HepG2 cells were significantly increased following miR-122 mimic transfection. Reverse transcription-polymerase chain reaction analysis revealed that Bcl-w mRNA was significantly reduced, while the mRNA levels of caspase-9 and caspase-3 were m …
The apoptotic rates of HepG2 cells were significantly increased following miR-122 mimic transfection. Reverse transcription-po …
Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway.
Wen Z, Mai Z, Zhu X, Wu T, Chen Y, Geng D, Wang J. Wen Z, et al. Stem Cell Res Ther. 2020 Jan 23;11(1):36. doi: 10.1186/s13287-020-1563-8. Stem Cell Res Ther. 2020. PMID: 31973741 Free PMC article.
BACKGROUND: A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. ...Treatment conditions tested included H9C2 cells pre-incubated with exosomes, …
BACKGROUND: A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardio …
Let-7a mimic transfection reduces chemotherapy-induced damage in a mouse ovarian transplantation model.
Alexandri C, Van Den Steen G, Demeestere I. Alexandri C, et al. Sci Rep. 2022 Jun 27;12(1):10863. doi: 10.1038/s41598-022-14926-z. Sci Rep. 2022. PMID: 35760952 Free PMC article.
Recently, we have investigated new targeted drugs based on microRNA (miRNA) replacement therapy, and have identified the let-7a miRNA as candidate for fertility preservation strategies. ...Newborn mouse ovaries were cultured under different conditions; control, chem …
Recently, we have investigated new targeted drugs based on microRNA (miRNA) replacement therapy, and have identified the let-7a mi …
The effects of miRNA-27a-3p on human epidermal melanocytes.
Li Y, Wang S, Ning J, Mao X, Ge K, Zhang R. Li Y, et al. Skin Res Technol. 2023 May;29(5):e13345. doi: 10.1111/srt.13345. Skin Res Technol. 2023. PMID: 37231929 Free PMC article.
METHODS: MCs were obtained from human foreskins and transfected with miRNA-27a-3p mimic (induces the overexpression of miRNA-27a-3p), mimic-NC (the negative control group), miRNA-27a-3p inhibitor, or inhibitor-NC. ...RESULTS: The RT-PCR r …
METHODS: MCs were obtained from human foreskins and transfected with miRNA-27a-3p mimic (induces the overexpression of …
Optimized workflow to modify microRNA expression in primary human intravascular cells.
Caglayan S, Hansen JB, Snir O. Caglayan S, et al. BMC Immunol. 2023 Feb 15;24(1):5. doi: 10.1186/s12865-023-00540-9. BMC Immunol. 2023. PMID: 36792999 Free PMC article.
BACKGROUND: A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requires a specific and efficient knockdown or overexpression of the miRNA of interest; these are achieved by transfecting the cel …
BACKGROUND: A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requ …
Manipulating Pericyte Function with MicroRNAs.
Vitiello M, Cathcart B, Caporali A, Meloni M. Vitiello M, et al. Methods Mol Biol. 2021;2235:139-153. doi: 10.1007/978-1-0716-1056-5_10. Methods Mol Biol. 2021. PMID: 33576975
MicroRNAs (miRNAs) are expressed in all cell types, including pericytes, and play essential roles in vascular development, homeostasis, and disease. ...Here we describe methods for manipulating pericyte function by using miRNA mimics and inhibitors. We …
MicroRNAs (miRNAs) are expressed in all cell types, including pericytes, and play essential roles in vascular development, hom …
Role of miRNA-542-5p in the tumorigenesis of osteosarcoma.
Zhu T, Fan D, Ye K, Liu B, Cui Z, Liu Z, Tian Y. Zhu T, et al. FEBS Open Bio. 2020 Apr;10(4):627-636. doi: 10.1002/2211-5463.12824. Epub 2020 Mar 18. FEBS Open Bio. 2020. PMID: 32105410 Free PMC article.
In this work, we identified miRNA-542-5p as a critical miRNA in osteosarcoma by overlapping three Gene Expression Omnibus datasets, and then evaluated miRNA-542-5p expression profiles using Gene Expression Omnibus and Sarcoma-microRNA Expression Database. We …
In this work, we identified miRNA-542-5p as a critical miRNA in osteosarcoma by overlapping three Gene Expression Omnibus data …
Manipulating MiRNA Expression to Uncover Hidden Functions.
Aherne ST, Lao NT. Aherne ST, et al. Methods Mol Biol. 2017;1509:151-160. doi: 10.1007/978-1-4939-6524-3_14. Methods Mol Biol. 2017. PMID: 27826925
There are a numerous target prediction algorithms that allow users to identify putative targets of their microRNAs (miRNAs) of interest. Although these tools are useful to gain insight into the potential role of miRNAs in regulating cellular processes, physic …
There are a numerous target prediction algorithms that allow users to identify putative targets of their microRNAs (miRNAs) of …
7,063 results

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