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It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.
Lima DJB, Almeida RG, Jardim GAM, Barbosa BPA, Santos ACC, Valença WO, Scheide MR, Gatto CC, de Carvalho GGC, Costa PMS, Pessoa C, Pereira CLM, Jacob C, Braga AL, da Silva Júnior EN. Lima DJB, et al. Among authors: da silva junior en. RSC Med Chem. 2021 Aug 12;12(10):1709-1721. doi: 10.1039/d1md00168j. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778772 Free PMC article.
Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblasts.
Cavalcanti BC, Barros FW, Cabral IO, Ferreira JR, Magalhães HI, Júnior HV, da Silva Júnior EN, de Abreu FC, Costa CO, Goulart MO, Moraes MO, Pessoa C. Cavalcanti BC, et al. Among authors: da silva junior en, junior hv. Chem Res Toxicol. 2011 Sep 19;24(9):1560-74. doi: 10.1021/tx200180y. Epub 2011 Aug 23. Chem Res Toxicol. 2011. PMID: 21830773
On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
da Silva Júnior EN, de Melo IM, Diogo EB, Costa VA, de Souza Filho JD, Valença WO, Camara CA, de Oliveira RN, de Araujo AS, Emery FS, dos Santos MR, de Simone CA, Menna-Barreto RF, de Castro SL. da Silva Júnior EN, et al. Eur J Med Chem. 2012 Jun;52:304-12. doi: 10.1016/j.ejmech.2012.03.039. Epub 2012 Mar 29. Eur J Med Chem. 2012. PMID: 22483633
Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety.
Diogo EB, Dias GG, Rodrigues BL, Guimarães TT, Valença WO, Camara CA, de Oliveira RN, da Silva MG, Ferreira VF, de Paiva YG, Goulart MO, Menna-Barreto RF, de Castro SL, da Silva Júnior EN. Diogo EB, et al. Among authors: da silva junior en, da silva mg. Bioorg Med Chem. 2013 Nov 1;21(21):6337-48. doi: 10.1016/j.bmc.2013.08.055. Epub 2013 Sep 6. Bioorg Med Chem. 2013. PMID: 24074878 Free article.
1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones.
da Cruz EH, Hussene CM, Dias GG, Diogo EB, de Melo IM, Rodrigues BL, da Silva MG, Valença WO, Camara CA, de Oliveira RN, de Paiva YG, Goulart MO, Cavalcanti BC, Pessoa C, da Silva Júnior EN. da Cruz EH, et al. Among authors: da silva junior en, da silva mg. Bioorg Med Chem. 2014 Mar 1;22(5):1608-19. doi: 10.1016/j.bmc.2014.01.033. Epub 2014 Jan 31. Bioorg Med Chem. 2014. PMID: 24530030 Free article.
84 results