Selective endocytic trafficking in live cells with fluorescent naphthoxazoles and their boron complexes

Gleiston G Dias; Bernardo L Rodrigues; Jarbas M Resende; Hállen D R Calado; Carlos A de Simone; Valter H C Silva; Brenno A D Neto; Marilia O F Goulart; Fabricia R Ferreira; Assuero S Meira; Claudia Pessoa; José R Correa; Eufrânio N da Silva Júnior

doi:10.1039/c5cc02383a

Selective endocytic trafficking in live cells with fluorescent naphthoxazoles and their boron complexes

Chem Commun (Camb). 2015 Jun 4;51(44):9141-4. doi: 10.1039/c5cc02383a.

Authors

Gleiston G Dias¹, Bernardo L Rodrigues, Jarbas M Resende, Hállen D R Calado, Carlos A de Simone, Valter H C Silva, Brenno A D Neto, Marilia O F Goulart, Fabricia R Ferreira, Assuero S Meira, Claudia Pessoa, José R Correa, Eufrânio N da Silva Júnior

Affiliation

¹ Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, 31270-901, MG, Brazil. eufranio@ufmg.br.

PMID: 25943956
DOI: 10.1039/c5cc02383a

Abstract

Fluorescent naphthoxazoles and their boron derivatives have been synthesized and applied as superior and selective probes for endocytic pathway tracking in live cancer cells. The best fluorophores were compared with the commercially available acridine orange (co-staining experiments), showing far better selectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies / pharmacology
Boron / chemistry
Boron / pharmacology*
Caveolin 1 / immunology
Caveolin 1 / metabolism
Cell Line, Tumor
Cell Survival / drug effects
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Endocytosis
Fluorescent Dyes / chemistry
Fluorescent Dyes / pharmacology*
Humans
Oxazoles / chemistry
Oxazoles / pharmacology*

Substances

Antibodies
CAV1 protein, human
Caveolin 1
Coordination Complexes
Fluorescent Dyes
Oxazoles
Boron