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The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells.
Oroń M, Grochowski M, Jaiswar A, Legierska J, Jastrzębski K, Nowak-Niezgoda M, Kołos M, Kaźmierczak W, Olesiński T, Lenarcik M, Cybulska M, Mikula M, Żylicz A, Miączyńska M, Zettl K, Wiśniewski JR, Walerych D. Oroń M, et al. Among authors: wisniewski jr. Cell Rep. 2022 Sep 27;40(13):111428. doi: 10.1016/j.celrep.2022.111428. Cell Rep. 2022. PMID: 36170818 Free article.
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer.
Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, Rajkowska K, Gaweda-Walerych K, Ingallina E, Tonelli C, Morelli MJ, Amato A, Eterno V, Zambelli A, Rosato A, Amati B, Wiśniewski JR, Del Sal G. Walerych D, et al. Among authors: wisniewski jr. Nat Cell Biol. 2016 Aug;18(8):897-909. doi: 10.1038/ncb3380. Epub 2016 Jun 27. Nat Cell Biol. 2016. PMID: 27347849 Free article.
'Shotgun' proteomic analyses without alkylation of cysteine.
Wiśniewski JR, Zettl K, Pilch M, Rysiewicz B, Sadok I. Wiśniewski JR, et al. Anal Chim Acta. 2020 Mar 1;1100:131-137. doi: 10.1016/j.aca.2019.12.007. Epub 2019 Dec 4. Anal Chim Acta. 2020. PMID: 31987133
188 results