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The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
Zacarías-Fluck MF, Jauset T, Martínez-Martín S, Kaur J, Casacuberta-Serra S, Massó-Vallés D, Serrano Del Pozo E, Martín-Fernández G, González-Larreategui Í, López-Estévez S, Brown-Swigart L, Beaulieu ME, Whitfield JR, Madan B, Virshup DM, Evan GI, Soucek L. Zacarías-Fluck MF, et al. Among authors: whitfield jr. Life Sci Alliance. 2021 Mar 2;4(5):e201900490. doi: 10.26508/lsa.201900490. Print 2021 May. Life Sci Alliance. 2021. PMID: 33653688 Free PMC article.
Modelling Myc inhibition as a cancer therapy.
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI. Soucek L, et al. Nature. 2008 Oct 2;455(7213):679-83. doi: 10.1038/nature07260. Epub 2008 Aug 17. Nature. 2008. PMID: 18716624 Free PMC article.
Tumor microenvironment: becoming sick of Myc.
Whitfield JR, Soucek L. Whitfield JR, et al. Cell Mol Life Sci. 2012 Mar;69(6):931-4. doi: 10.1007/s00018-011-0860-x. Epub 2011 Oct 28. Cell Mol Life Sci. 2012. PMID: 22033838 Free PMC article. Review.
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis.
Annibali D, Whitfield JR, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir NM, Massó-Vallés D, Beaulieu ME, Swigart LB, Mc Gee MM, Somma MP, Nasi S, Seoane J, Evan GI, Soucek L. Annibali D, et al. Among authors: whitfield jr. Nat Commun. 2014 Aug 18;5:4632. doi: 10.1038/ncomms5632. Nat Commun. 2014. PMID: 25130259 Free PMC article.
Tamoxifen administration to mice.
Whitfield J, Littlewood T, Soucek L. Whitfield J, et al. Cold Spring Harb Protoc. 2015 Mar 2;2015(3):269-71. doi: 10.1101/pdb.prot077966. Cold Spring Harb Protoc. 2015. PMID: 25734062 Free PMC article.
Strategies to Inhibit Myc and Their Clinical Applicability.
Whitfield JR, Beaulieu ME, Soucek L. Whitfield JR, et al. Front Cell Dev Biol. 2017 Feb 23;5:10. doi: 10.3389/fcell.2017.00010. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 28280720 Free PMC article. Review.
112 results