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In Vitro Model Systems to Study Human T Cell Development.
Lambrechts N, Liang KL, Velghe I, Strubbe S, Dolens AC, Taghon T. Lambrechts N, et al. Among authors: velghe i. Methods Mol Biol. 2023;2580:335-354. doi: 10.1007/978-1-0716-2740-2_21. Methods Mol Biol. 2023. PMID: 36374468 Review.
Generation of T cells from human embryonic stem cell-derived hematopoietic zones.
Timmermans F, Velghe I, Vanwalleghem L, De Smedt M, Van Coppernolle S, Taghon T, Moore HD, Leclercq G, Langerak AW, Kerre T, Plum J, Vandekerckhove B. Timmermans F, et al. Among authors: velghe i. J Immunol. 2009 Jun 1;182(11):6879-88. doi: 10.4049/jimmunol.0803670. J Immunol. 2009. PMID: 19454684
In vitro generation of immune cells from pluripotent stem cells.
Vandekerckhove B, Vanhee S, Van Coppernolle S, Snauwaert S, Velghe I, Taghon T, Leclercq G, Kerre T, Plum J. Vandekerckhove B, et al. Among authors: velghe i. Front Biosci (Landmark Ed). 2011 Jan 1;16(4):1488-504. doi: 10.2741/3800. Front Biosci (Landmark Ed). 2011. PMID: 21196243 Free article. Review.
Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.
Van Coppernolle S, Vanhee S, Verstichel G, Snauwaert S, van der Spek A, Velghe I, Sinnesael M, Heemskerk MH, Taghon T, Leclercq G, Plum J, Langerak AW, Kerre T, Vandekerckhove B. Van Coppernolle S, et al. Among authors: velghe i. Leukemia. 2012 Jan;26(1):127-38. doi: 10.1038/leu.2011.324. Epub 2011 Nov 4. Leukemia. 2012. PMID: 22051534
RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia.
Snauwaert S, Vanhee S, Goetgeluk G, Verstichel G, Van Caeneghem Y, Velghe I, Philippé J, Berneman ZN, Plum J, Taghon T, Leclercq G, Thielemans K, Kerre T, Vandekerckhove B. Snauwaert S, et al. Among authors: velghe i. Haematologica. 2012 Oct;97(10):1539-47. doi: 10.3324/haematol.2012.065581. Epub 2012 Apr 24. Haematologica. 2012. PMID: 22532518 Free PMC article.
In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis.
Vanhee S, De Mulder K, Van Caeneghem Y, Verstichel G, Van Roy N, Menten B, Velghe I, Philippé J, De Bleser D, Lambrecht BN, Taghon T, Leclercq G, Kerre T, Vandekerckhove B. Vanhee S, et al. Among authors: velghe i. Haematologica. 2015 Feb;100(2):157-66. doi: 10.3324/haematol.2014.112144. Epub 2014 Nov 7. Haematologica. 2015. PMID: 25381126 Free PMC article.
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.
Van de Walle I, Dolens AC, Durinck K, De Mulder K, Van Loocke W, Damle S, Waegemans E, De Medts J, Velghe I, De Smedt M, Vandekerckhove B, Kerre T, Plum J, Leclercq G, Rothenberg EV, Van Vlierberghe P, Speleman F, Taghon T. Van de Walle I, et al. Among authors: velghe i. Nat Commun. 2016 Apr 6;7:11171. doi: 10.1038/ncomms11171. Nat Commun. 2016. PMID: 27048872 Free PMC article.
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development.
Dolens AC, Durinck K, Lavaert M, Van der Meulen J, Velghe I, De Medts J, Weening K, Roels J, De Mulder K, Volders PJ, De Preter K, Kerre T, Vandekerckhove B, Leclercq G, Vandesompele J, Mestdagh P, Van Vlierberghe P, Speleman F, Taghon T. Dolens AC, et al. Among authors: velghe i. EMBO Rep. 2020 May 6;21(5):e49006. doi: 10.15252/embr.201949006. Epub 2020 Apr 7. EMBO Rep. 2020. PMID: 32255245 Free PMC article.
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.
Liang KL, Roels J, Lavaert M, Putteman T, Boehme L, Tilleman L, Velghe I, Pegoretti V, Van de Walle I, Sontag S, Vandewalle J, Vandekerckhove B, Leclercq G, Van Vlierberghe P, Libert C, Van Nieuwerburgh F, Fischer R, Kontermann RE, Pfizenmaier K, Doody G, Zenke M, Taghon T. Liang KL, et al. Among authors: velghe i. Nat Immunol. 2023 Mar;24(3):474-486. doi: 10.1038/s41590-022-01417-6. Epub 2023 Jan 26. Nat Immunol. 2023. PMID: 36703005 Free article.
14 results