Späth GF - Search Results

1

Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response.

Lecoeur H, Prina E, Rosazza T, Kokou K, N'Diaye P, Aulner N, Varet H, Bussotti G, Xing Y, Milon G, Weil R, Meng G, Späth GF. Lecoeur H, et al. Among authors: spath gf. Cell Rep. 2020 Feb 11;30(6):1870-1882.e4. doi: 10.1016/j.celrep.2020.01.030. Cell Rep. 2020. PMID: 32049017 Free article.

2

The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.

Horjales S, Schmidt-Arras D, Limardo RR, Leclercq O, Obal G, Prina E, Turjanski AG, Späth GF, Buschiazzo A. Horjales S, et al. Among authors: spath gf. Structure. 2012 Oct 10;20(10):1649-60. doi: 10.1016/j.str.2012.07.005. Epub 2012 Aug 9. Structure. 2012. PMID: 22884419 Free article.

3

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E. Aulner N, et al. Among authors: spath gf. PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2154. doi: 10.1371/journal.pntd.0002154. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23593521 Free PMC article.

4

[Leishmania epidemiology, diagnosis, chemotherapy and vaccination approaches in the international network of Pasteur Institutes].

Louzir H, Aoun K, Späth GF, Laouini D, Prina E, Victoir K, Bouratbine A. Louzir H, et al. Among authors: spath gf. Med Sci (Paris). 2013 Dec;29(12):1151-60. doi: 10.1051/medsci/20132912020. Epub 2013 Dec 20. Med Sci (Paris). 2013. PMID: 24356147 Free article. French.

5

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.

Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF. Rachidi N, et al. Among authors: spath gf. Antimicrob Agents Chemother. 2014;58(3):1501-15. doi: 10.1128/AAC.02022-13. Epub 2013 Dec 23. Antimicrob Agents Chemother. 2014. PMID: 24366737 Free PMC article.

6

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.

Dacher M, Morales MA, Pescher P, Leclercq O, Rachidi N, Prina E, Cayla M, Descoteaux A, Späth GF. Dacher M, et al. Among authors: spath gf. Mol Microbiol. 2014 Jul;93(1):146-66. doi: 10.1111/mmi.12648. Epub 2014 Jun 3. Mol Microbiol. 2014. PMID: 24823804 Free article.

7

Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process.

Forestier CL, Späth GF, Prina E, Dasari S. Forestier CL, et al. Among authors: spath gf. Microb Pathog. 2015 Nov;88:103-8. doi: 10.1016/j.micpath.2014.10.012. Epub 2014 Oct 31. Microb Pathog. 2015. PMID: 25448129 Review.

8

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

Durieu E, Prina E, Leclercq O, Oumata N, Gaboriaud-Kolar N, Vougogiannopoulou K, Aulner N, Defontaine A, No JH, Ruchaud S, Skaltsounis AL, Galons H, Späth GF, Meijer L, Rachidi N. Durieu E, et al. Among authors: spath gf. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2822-33. doi: 10.1128/AAC.00021-16. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26902771 Free PMC article.

9

Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy.

Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Späth GF, Meng G. Javed N, et al. Among authors: spath gf. Cytokine. 2016 May;81:101-8. doi: 10.1016/j.cyto.2016.03.007. Epub 2016 Mar 12. Cytokine. 2016. PMID: 26978550 Free article.

10

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.

Bendjeddou LZ, Loaëc N, Villiers B, Prina E, Späth GF, Galons H, Meijer L, Oumata N. Bendjeddou LZ, et al. Among authors: spath gf. Eur J Med Chem. 2017 Jan 5;125:696-709. doi: 10.1016/j.ejmech.2016.09.064. Epub 2016 Sep 22. Eur J Med Chem. 2017. PMID: 27721154 Free article.

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