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Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. Among authors: shuster cb. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.
Magedov IV, Frolova L, Manpadi M, Bhoga Ud, Tang H, Evdokimov NM, George O, Georgiou KH, Renner S, Getlik M, Kinnibrugh TL, Fernandes MA, Van slambrouck S, Steelant WF, Shuster CB, Rogelj S, van Otterlo WA, Kornienko A. Magedov IV, et al. Among authors: shuster cb. J Med Chem. 2011 Jun 23;54(12):4234-46. doi: 10.1021/jm200410r. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615090 Free PMC article.
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.
Rodriguez D, Ramesh C, Henson LH, Wilmeth L, Bryant BK, Kadavakollu S, Hirsch R, Montoya J, Howell PR, George JM, Alexander D, Johnson DL, Arterburn JB, Shuster CB. Rodriguez D, et al. Among authors: shuster cb. Bioorg Med Chem. 2011 Sep 15;19(18):5446-53. doi: 10.1016/j.bmc.2011.07.054. Epub 2011 Jul 30. Bioorg Med Chem. 2011. PMID: 21855351 Free PMC article.
Reengineered epipodophyllotoxin.
Magedov IV, Evdokimov NM, Karki M, Peretti AS, Lima DT, Frolova LV, Reisenauer MR, Romero AE, Tongwa P, Fonari A, Altig J, Rogelj S, Antipin MY, Shuster CB, Kornienko A. Magedov IV, et al. Among authors: shuster cb. Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k. Epub 2012 Sep 17. Chem Commun (Camb). 2012. PMID: 22986348 Free PMC article.
Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins.
Scott R, Karki M, Reisenauer MR, Rodrigues R, Dasari R, Smith WR, Pelly SC, van Otterlo WAL, Shuster CB, Rogelj S, Magedov IV, Frolova LV, Kornienko A. Scott R, et al. Among authors: shuster cb. ChemMedChem. 2014 Jul;9(7):1428-1435. doi: 10.1002/cmdc.201300532. Epub 2014 Mar 18. ChemMedChem. 2014. PMID: 24644272 Free PMC article.
Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.
Medellin DC, Zhou Q, Scott R, Hill RM, Frail SK, Dasari R, Ontiveros SJ, Pelly SC, van Otterlo WA, Betancourt T, Shuster CB, Hamel E, Bai R, LaBarbera DV, Rogelj S, Frolova LV, Kornienko A. Medellin DC, et al. Among authors: shuster cb. J Med Chem. 2016 Jan 14;59(1):480-5. doi: 10.1021/acs.jmedchem.5b01426. Epub 2015 Dec 17. J Med Chem. 2016. PMID: 26641132 Free PMC article.
Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins.
Dasari R, Błauż A, Medellin DC, Kassim RM, Viera C, Santarosa M, van der Westhuyzen AE, van Otterlo WAL, Olivas T, Yildiz T, Betancourt T, Shuster CB, Rogelj S, Rychlik B, Hudnall T, Frolova LV, Kornienko A. Dasari R, et al. Among authors: shuster cb. ChemMedChem. 2019 Feb 5;14(3):322-333. doi: 10.1002/cmdc.201800658. Epub 2019 Jan 25. ChemMedChem. 2019. PMID: 30562414 Free PMC article.
SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.
Chiang YC, Park IY, Terzo EA, Tripathi DN, Mason FM, Fahey CC, Karki M, Shuster CB, Sohn BH, Chowdhury P, Powell RT, Ohi R, Tsai YS, de Cubas AA, Khan A, Davis IJ, Strahl BD, Parker JS, Dere R, Walker CL, Rathmell WK. Chiang YC, et al. Among authors: shuster cb. Cancer Res. 2018 Jun 15;78(12):3135-3146. doi: 10.1158/0008-5472.CAN-17-3460. Epub 2018 May 3. Cancer Res. 2018. PMID: 29724720 Free PMC article.
45 results