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Page 1
Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels.
Chen YT, Hong MR, Zhang XJ, Kostas J, Li Y, Kraus RL, Santarelli VP, Wang D, Gomez-Llorente Y, Brooun A, Strickland C, Soisson SM, Klein DJ, Ginnetti AT, Marino MJ, Stachel SJ, Ishchenko A. Chen YT, et al. Among authors: santarelli vp. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2220029120. doi: 10.1073/pnas.2220029120. Epub 2023 Oct 9. Proc Natl Acad Sci U S A. 2023. PMID: 37812700 Free PMC article.
Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3).
Coburn CA, Luo Y, Cui M, Wang J, Soll R, Dong J, Hu B, Lyon MA, Santarelli VP, Kraus RL, Gregan Y, Wang Y, Fox SV, Binns J, Doran SM, Reiss DR, Tannenbaum PL, Gotter AL, Meinke PT, Renger JJ. Coburn CA, et al. Among authors: santarelli vp. ChemMedChem. 2012 Jan 2;7(1):123-33. doi: 10.1002/cmdc.201100351. Epub 2011 Sep 14. ChemMedChem. 2012. PMID: 21916012
TASK-3 as a potential antidepressant target.
Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K, McCampbell A, Stevens J, Brunner JI, Fox SV, Uebele VN, Bayliss DA, Winrow CJ, Renger JJ. Gotter AL, et al. Among authors: santarelli vp. Brain Res. 2011 Oct 6;1416:69-79. doi: 10.1016/j.brainres.2011.08.021. Epub 2011 Aug 16. Brain Res. 2011. PMID: 21885038 Free PMC article.
Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.
Uebele VN, Nuss CE, Fox SV, Garson SL, Cristescu R, Doran SM, Kraus RL, Santarelli VP, Li Y, Barrow JC, Yang ZQ, Schlegel KA, Rittle KE, Reger TS, Bednar RA, Lemaire W, Mullen FA, Ballard JE, Tang C, Dai G, McManus OB, Koblan KS, Renger JJ. Uebele VN, et al. Among authors: santarelli vp. Cell Biochem Biophys. 2009;55(2):81-93. doi: 10.1007/s12013-009-9057-4. Epub 2009 Jul 7. Cell Biochem Biophys. 2009. PMID: 19582593
T-type calcium channels regulate cortical plasticity in-vivo. [corrected].
Uebele VN, Nuss CE, Santarelli VP, Garson SL, Kraus RL, Barrow JC, Stauffer SR, Koblan KS, Renger JJ, Aton S, Seibt J, Dumoulin M, Jha SK, Coleman T, Frank MG. Uebele VN, et al. Among authors: santarelli vp. Neuroreport. 2009 Feb 18;20(3):257-62. doi: 10.1097/WNR.0b013e3283200111. Neuroreport. 2009. PMID: 19212242 Free PMC article.