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A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma.
Groot J, Ott M, Wei J, Kassab C, Fang D, Najem H, O'Brien B, Weathers SP, Matsouka CK, Majd NK, Harrison RA, Fuller GN, Huse JT, Long JP, Sawaya R, Rao G, MacDonald TJ, Priebe W, DeCuypere M, Heimberger AB. Groot J, et al. Among authors: priebe w. CNS Oncol. 2022 Jun 1;11(2):CNS87. doi: 10.2217/cns-2022-0005. Epub 2022 May 16. CNS Oncol. 2022. PMID: 35575067 Free PMC article. Clinical Trial.
Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy.
Ott M, Kassab C, Marisetty A, Hashimoto Y, Wei J, Zamler D, Leu JS, Tomaszowski KH, Sabbagh A, Fang D, Gupta P, Priebe W, Zielinski RJ, Burks JK, Long JP, Kong LY, Fuller GN, DeGroot J, Sulman EP, Heimberger AB. Ott M, et al. Among authors: priebe w. Clin Cancer Res. 2020 Sep 15;26(18):4983-4994. doi: 10.1158/1078-0432.CCR-19-4092. Epub 2020 Jun 30. Clin Cancer Res. 2020. PMID: 32605912 Free PMC article.
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells.
Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE Jr, Sampson JH, Priebe W, Heimberger AB. Kong LY, et al. Among authors: priebe w. Clin Cancer Res. 2008 Sep 15;14(18):5759-68. doi: 10.1158/1078-0432.CCR-08-0377. Clin Cancer Res. 2008. PMID: 18794085 Free PMC article.
Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway.
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Wei J, et al. Among authors: priebe w. Mol Cancer Ther. 2010 Jan;9(1):67-78. doi: 10.1158/1535-7163.MCT-09-0734. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053772 Free PMC article.
203 results