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Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids.
Luther JM, Wei DS, Ghoshal K, Peng D, Adler GK, Turcu AF, Nian H, Yu C, Solorzano CC, Pozzi A, Brown NJ. Luther JM, et al. Among authors: pozzi a. Hypertension. 2021 Apr;77(4):1323-1331. doi: 10.1161/HYPERTENSIONAHA.120.14808. Epub 2021 Feb 15. Hypertension. 2021. PMID: 33583202 Free PMC article.
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Gangadhariah MH, et al. Among authors: pozzi a. J Am Soc Nephrol. 2015 Mar;26(3):597-610. doi: 10.1681/ASN.2013090980. Epub 2014 Jul 28. J Am Soc Nephrol. 2015. PMID: 25071086 Free PMC article.
Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.
Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM. Gangadhariah MH, et al. Among authors: pozzi a. Diabetologia. 2017 Jun;60(6):1066-1075. doi: 10.1007/s00125-017-4260-0. Epub 2017 Mar 28. Diabetologia. 2017. PMID: 28352940 Free PMC article.
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. Sausville LN, et al. Among authors: pozzi a. Cancer Res. 2018 Sep 1;78(17):4865-4877. doi: 10.1158/0008-5472.CAN-17-3977. Epub 2018 Jul 16. Cancer Res. 2018. PMID: 30012669 Free PMC article.
The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells.
Mashayekhi M, Wanjalla CN, Warren CM, Simmons JD, Ghoshal K, Pilkinton M, Bailin SS, Gabriel CL, Pozzi A, Koethe JR, Brown NJ, Kalams SA, Luther JM. Mashayekhi M, et al. Among authors: pozzi a. Prostaglandins Other Lipid Mediat. 2022 Feb;158:106604. doi: 10.1016/j.prostaglandins.2021.106604. Epub 2021 Dec 15. Prostaglandins Other Lipid Mediat. 2022. PMID: 34922004 Free PMC article.
594 results