Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids

Hypertension. 2021 Apr;77(4):1323-1331. doi: 10.1161/HYPERTENSIONAHA.120.14808. Epub 2021 Feb 15.

James M Luther¹, Dawei S Wei¹, Kakali Ghoshal², Dungeng Peng¹, Gail K Adler³, Adina F Turcu⁴, Hui Nian⁵, Chang Yu⁵, Carmen C Solorzano⁶, Ambra Pozzi^{2

7}, Nancy J Brown^{1

8}

¹ From the Division of Clinical Pharmacology (J.M.L., D.S.W., D.P., N.J.B.), Vanderbilt University Medical Center.
² Division of Nephrology and Hypertension (K.G., A.P.), Vanderbilt University Medical Center.
³ Division of Endocrinology and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School (G.K.A.).
⁴ Division of Endocrinology, Department of Medicine, University of Michigan (A.F.T.).
⁵ Department of Biostatistics, Vanderbilt University (H.N., C.Y.).
⁶ Department of Medicine and Department of Surgery (C.C.S.), Vanderbilt University Medical Center.
⁷ Department of Veterans Affairs, Nashville, TN (A.P.).
⁸ Yale School of Medicine (N.J.B.).

Abstract

[Figure: see text].

Keywords: aldosterone; eicosanoids; hypertension; insulin resistance; mineralocorticoids.