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Safety perspectives on presently considered drugs for the treatment of COVID-19.
Penman SL, Kiy RT, Jensen RL, Beoku-Betts C, Alfirevic A, Back D, Khoo SH, Owen A, Pirmohamed M, Park BK, Meng X, Goldring CE, Chadwick AE. Penman SL, et al. Br J Pharmacol. 2020 Oct;177(19):4353-4374. doi: 10.1111/bph.15204. Epub 2020 Aug 13. Br J Pharmacol. 2020. PMID: 32681537 Free PMC article. Review.
The mitochondrial paradox.
Penman SL, Jensen RL, Kiy RT, Chadwick AE. Penman SL, et al. Elife. 2020 Jun 25;9:e59140. doi: 10.7554/eLife.59140. Elife. 2020. PMID: 32583799 Free PMC article.
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly CE, Douglas O, Kamalian L, Jenkins RE, Beckett AJ, Penman SL, Williams DP, Monshouwer M, Simic D, Snoeys J, Park BK, Chadwick AE. Jolly CE, et al. Among authors: penman sl. Toxicol Appl Pharmacol. 2020 Sep 15;403:115163. doi: 10.1016/j.taap.2020.115163. Epub 2020 Jul 28. Toxicol Appl Pharmacol. 2020. PMID: 32730777 Free PMC article.
First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug.
Pieren M, Abáigar Gutiérrez-Solana A, Antonijoan Arbós RM, Boyle GW, Davila M, Davy M, Gitzinger M, Husband L, Martínez-Martínez MS, Mazarro DO, Pefani E, Penman SL, Remuiñán MJ, Vlasakakis G, Zeitlinger M, Dale GE. Pieren M, et al. Among authors: penman sl. J Antimicrob Chemother. 2024 Apr 24:dkae107. doi: 10.1093/jac/dkae107. Online ahead of print. J Antimicrob Chemother. 2024. PMID: 38656557
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial.
Diacon AH, Barry CE 3rd, Carlton A, Chen RY, Davies M, de Jager V, Fletcher K, Koh GCKW, Kontsevaya I, Heyckendorf J, Lange C, Reimann M, Penman SL, Scott R, Maher-Edwards G, Tiberi S, Vlasakakis G, Upton CM, Aguirre DB. Diacon AH, et al. Among authors: penman sl. Nat Med. 2024 Mar;30(3):896-904. doi: 10.1038/s41591-024-02829-7. Epub 2024 Feb 16. Nat Med. 2024. PMID: 38365949 Free PMC article. Clinical Trial.
14 results