The mitochondrial paradox

Sophie L Penman; Rebecca L Jensen; Robyn T Kiy; Amy E Chadwick

doi:10.7554/eLife.59140

The mitochondrial paradox

Elife. 2020 Jun 25:9:e59140. doi: 10.7554/eLife.59140.

Authors

Sophie L Penman^{1

2}, Rebecca L Jensen^{1

2}, Robyn T Kiy^{1

2}, Amy E Chadwick^{1

2}

Affiliations

¹ MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, United Kingdom.
² Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

Abstract

A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs.

Keywords: anti-cancer drugs; biochemistry; cancer biology; cardiac liability; chemical biology; human; mitochondria; toxicophore.

Publication types

Comment

MeSH terms

Antineoplastic Agents*
Drug-Related Side Effects and Adverse Reactions*
Electron Transport Complex I
Humans
Mitochondria
Neoplasms*

Substances

Antineoplastic Agents
Electron Transport Complex I