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Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy.
Nelson CE, Wu Y, Gemberling MP, Oliver ML, Waller MA, Bohning JD, Robinson-Hamm JN, Bulaklak K, Castellanos Rivera RM, Collier JH, Asokan A, Gersbach CA. Nelson CE, et al. Nat Med. 2019 Mar;25(3):427-432. doi: 10.1038/s41591-019-0344-3. Epub 2019 Feb 18. Nat Med. 2019. PMID: 30778238 Free PMC article.
Cas9 loosens its grip on off-target sites.
Nelson CE, Gersbach CA. Nelson CE, et al. Nat Biotechnol. 2016 Mar;34(3):298-9. doi: 10.1038/nbt.3501. Nat Biotechnol. 2016. PMID: 26963555 No abstract available.
Engineering Delivery Vehicles for Genome Editing.
Nelson CE, Gersbach CA. Nelson CE, et al. Annu Rev Chem Biomol Eng. 2016 Jun 7;7:637-62. doi: 10.1146/annurev-chembioeng-080615-034711. Epub 2016 Apr 21. Annu Rev Chem Biomol Eng. 2016. PMID: 27146557 Review.
Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.
Huang J, Chen M, Whitley MJ, Kuo HC, Xu ES, Walens A, Mowery YM, Van Mater D, Eward WC, Cardona DM, Luo L, Ma Y, Lopez OM, Nelson CE, Robinson-Hamm JN, Reddy A, Dave SS, Gersbach CA, Dodd RD, Kirsch DG. Huang J, et al. Among authors: nelson ce. Nat Commun. 2017 Jul 10;8:15999. doi: 10.1038/ncomms15999. Nat Commun. 2017. PMID: 28691711 Free PMC article.
AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.
Hakim CH, Wasala NB, Nelson CE, Wasala LP, Yue Y, Louderman JA, Lessa TB, Dai A, Zhang K, Jenkins GJ, Nance ME, Pan X, Kodippili K, Yang NN, Chen SJ, Gersbach CA, Duan D. Hakim CH, et al. Among authors: nelson ce. JCI Insight. 2018 Dec 6;3(23):e124297. doi: 10.1172/jci.insight.124297. JCI Insight. 2018. PMID: 30518686 Free PMC article.
Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.
Pickar-Oliver A, Black JB, Lewis MM, Mutchnick KJ, Klann TS, Gilcrest KA, Sitton MJ, Nelson CE, Barrera A, Bartelt LC, Reddy TE, Beisel CL, Barrangou R, Gersbach CA. Pickar-Oliver A, et al. Among authors: nelson ce. Nat Biotechnol. 2019 Dec;37(12):1493-1501. doi: 10.1038/s41587-019-0235-7. Epub 2019 Sep 23. Nat Biotechnol. 2019. PMID: 31548729 Free PMC article.
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.
Hakim CH, Kumar SRP, Pérez-López DO, Wasala NB, Zhang D, Yue Y, Teixeira J, Pan X, Zhang K, Million ED, Nelson CE, Metzger S, Han J, Louderman JA, Schmidt F, Feng F, Grimm D, Smith BF, Yao G, Yang NN, Gersbach CA, Chen SJ, Herzog RW, Duan D. Hakim CH, et al. Among authors: nelson ce. Nat Commun. 2021 Nov 24;12(1):6769. doi: 10.1038/s41467-021-26830-7. Nat Commun. 2021. PMID: 34819506 Free PMC article.
239 results