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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Linder SJ, Bernasocchi T, Martínez-Pastor B, Sullivan KD, Galbraith MD, Lewis CA, Ferrer CM, Boon R, Silveira GG, Cho HM, Vidoudez C, Shroff S, Oliveira-Costa JP, Ross KN, Massri R, Matoba Y, Kim E, Rueda BR, Stott SL, Gottlieb E, Espinosa JM, Mostoslavsky R. Linder SJ, et al. Among authors: mostoslavsky r. Nat Metab. 2023 Dec;5(12):2131-2147. doi: 10.1038/s42255-023-00919-3. Epub 2023 Nov 13. Nat Metab. 2023. PMID: 37957387
Nuclear metabolism and the regulation of the epigenome.
Boon R, Silveira GG, Mostoslavsky R. Boon R, et al. Among authors: mostoslavsky r. Nat Metab. 2020 Nov;2(11):1190-1203. doi: 10.1038/s42255-020-00285-4. Epub 2020 Oct 12. Nat Metab. 2020. PMID: 33046909 Review.
Sirtuins, metabolism, and cancer.
Martinez-Pastor B, Mostoslavsky R. Martinez-Pastor B, et al. Among authors: mostoslavsky r. Front Pharmacol. 2012 Feb 21;3:22. doi: 10.3389/fphar.2012.00022. eCollection 2012. Front Pharmacol. 2012. PMID: 22363287 Free PMC article.
Cancer and metabolism: Why should we care?
Gottlieb E, Mostoslavsky R. Gottlieb E, et al. Among authors: mostoslavsky r. Semin Cell Dev Biol. 2015 Jul;43:1-2. doi: 10.1016/j.semcdb.2015.10.007. Semin Cell Dev Biol. 2015. PMID: 26611348 No abstract available.
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.
Choi JE, Sebastian C, Ferrer CM, Lewis CA, Sade-Feldman M, LaSalle T, Gonye A, Lopez BGC, Abdelmoula WM, Regan MS, Cetinbas M, Pascual G, Wojtkiewicz GR, Silveira GG, Boon R, Ross KN, Tirosh I, Saladi SV, Ellisen LW, Sadreyev RI, Benitah SA, Agar NYR, Hacohen N, Mostoslavsky R. Choi JE, et al. Among authors: mostoslavsky r. Nat Metab. 2021 Feb;3(2):182-195. doi: 10.1038/s42255-021-00350-6. Epub 2021 Feb 22. Nat Metab. 2021. PMID: 33619381 Free PMC article.
SIRT6, a Mammalian Deacylase with Multitasking Abilities.
Chang AR, Ferrer CM, Mostoslavsky R. Chang AR, et al. Among authors: mostoslavsky r. Physiol Rev. 2020 Jan 1;100(1):145-169. doi: 10.1152/physrev.00030.2018. Epub 2019 Aug 22. Physiol Rev. 2020. PMID: 31437090 Free PMC article. Review.
Assaying chromatin sirtuins.
Zhong L, Martinez-Pastor B, Silberman DM, Sebastian C, Mostoslavsky R. Zhong L, et al. Among authors: mostoslavsky r. Methods Mol Biol. 2013;1077:149-163. doi: 10.1007/978-1-62703-637-5_10. Methods Mol Biol. 2013. PMID: 24014405 Free PMC article.
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R. Etchegaray JP, et al. Among authors: mostoslavsky r, mostoslavsky g. Nat Cell Biol. 2015 May;17(5):545-57. doi: 10.1038/ncb3147. Epub 2015 Apr 27. Nat Cell Biol. 2015. PMID: 25915124 Free PMC article.
117 results