Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair

Samantha J Linder; Raul Mostoslavsky

doi:10.1016/j.molcel.2017.07.006

Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair

Mol Cell. 2017 Jul 20;67(2):165-167. doi: 10.1016/j.molcel.2017.07.006.

Authors

Samantha J Linder¹, Raul Mostoslavsky²

Affiliations

¹ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; The Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA.
² Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; The Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: rmostoslavsky@mgh.harvard.edu.

PMID: 28732204
DOI: 10.1016/j.molcel.2017.07.006

Abstract

In this issue of Molecular Cell, Sivanand et al. (2017) describe the importance for nuclear ACLY-mediated production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent HR-mediated DNA repair in response to DNA damage, thus drawing a direct link between DNA repair and cellular metabolism.

MeSH terms

Acetyl Coenzyme A*
Acetylation
DNA Damage
DNA Repair*
Histones
Protein Processing, Post-Translational

Substances

Histones
Acetyl Coenzyme A