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Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle.
Lamboley CR, Pearce L, Seng C, Meizoso-Huesca A, Singh DP, Frankish BP, Kaura V, Lo HP, Ferguson C, Allen PD, Hopkins PM, Parton RG, Murphy RM, van der Poel C, Barclay CJ, Launikonis BS. Lamboley CR, et al. Among authors: meizoso huesca a. Sci Adv. 2021 Oct 29;7(44):eabi7166. doi: 10.1126/sciadv.abi7166. Epub 2021 Oct 27. Sci Adv. 2021. PMID: 34705503 Free PMC article.
A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions.
Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR. Azimi I, et al. Among authors: meizoso huesca a. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147. doi: 10.1021/acsptsci.9b00081. Epub 2020 Jan 13. ACS Pharmacol Transl Sci. 2020. PMID: 32190822 Free PMC article.
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