Luo X - Search Results

1

Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.

Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X. Bao W, et al. Among authors: luo x. Sci Adv. 2023 Sep;9(35):eadh5016. doi: 10.1126/sciadv.adh5016. Epub 2023 Aug 30. Sci Adv. 2023. PMID: 37647408 Free PMC article.

2

Sequence-based drug design as a concept in computational drug design.

Chen L, Fan Z, Chang J, Yang R, Hou H, Guo H, Zhang Y, Yang T, Zhou C, Sui Q, Chen Z, Zheng C, Hao X, Zhang K, Cui R, Zhang Z, Ma H, Ding Y, Zhang N, Lu X, Luo X, Jiang H, Zhang S, Zheng M. Chen L, et al. Among authors: luo x. Nat Commun. 2023 Jul 14;14(1):4217. doi: 10.1038/s41467-023-39856-w. Nat Commun. 2023. PMID: 37452028 Free PMC article.

3

Drug target inference by mining transcriptional data using a novel graph convolutional network framework.

Zhong F, Wu X, Yang R, Li X, Wang D, Fu Z, Liu X, Wan X, Yang T, Fan Z, Zhang Y, Luo X, Chen K, Zhang S, Jiang H, Zheng M. Zhong F, et al. Among authors: luo x. Protein Cell. 2022 Apr;13(4):281-301. doi: 10.1007/s13238-021-00885-0. Epub 2021 Oct 22. Protein Cell. 2022. PMID: 34677780 Free PMC article.

4

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.

Song J, Yang RR, Chang J, Liu YD, Lu CH, Chen LF, Guo H, Zhang YH, Fan ZS, Zhou JY, Zhou GZ, Zhang KK, Luo XM, Chen KX, Jiang HL, Zhang SL, Zheng MY. Song J, et al. Acta Pharmacol Sin. 2023 Apr;44(4):791-800. doi: 10.1038/s41401-022-01002-5. Epub 2022 Oct 13. Acta Pharmacol Sin. 2023. PMID: 36229599 Free PMC article.

5

KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling.

Ren Q, Qu N, Sun J, Zhou J, Liu J, Ni L, Tong X, Zhang Z, Kong X, Wen Y, Wang Y, Wang D, Luo X, Zhang S, Zheng M, Li X. Ren Q, et al. Among authors: luo x. Brief Bioinform. 2023 Nov 22;25(1):bbad461. doi: 10.1093/bib/bbad461. Brief Bioinform. 2023. PMID: 38113075 Free PMC article.

6

Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening.

Zhang G, Xing J, Wang Y, Wang L, Ye Y, Lu D, Zhao J, Luo X, Zheng M, Yan S. Zhang G, et al. Among authors: luo x. Front Pharmacol. 2018 Mar 29;9:277. doi: 10.3389/fphar.2018.00277. eCollection 2018. Front Pharmacol. 2018. PMID: 29651242 Free PMC article.

7

Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR.

Zheng M, Li C, Zhou M, Jia R, Cai G, She F, Wei L, Wang S, Yu J, Wang D, Calcul L, Sun X, Luo X, Cheng F, Li Q, Wang Y, Cai J. Zheng M, et al. Among authors: luo x. J Med Chem. 2021 Aug 12;64(15):11219-11228. doi: 10.1021/acs.jmedchem.1c00607. Epub 2021 Jul 23. J Med Chem. 2021. PMID: 34297567

8

Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader.

Hu L, Li H, Qin J, Yang D, Liu J, Luo X, Ma J, Luo C, Ye F, Zhou Y, Li J, Wang M. Hu L, et al. Among authors: luo c, luo x. J Med Chem. 2023 Nov 23;66(22):15269-15287. doi: 10.1021/acs.jmedchem.3c01348. Epub 2023 Nov 15. J Med Chem. 2023. PMID: 37966047

9

Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis.

Tan Y, Sun X, Xu Y, Tang B, Xu S, Lu D, Ye Y, Luo X, Diao X, Li F, Wang T, Chen J, Xu Q, Wu X. Tan Y, et al. Among authors: luo x. Nucleic Acids Res. 2022 Mar 21;50(5):2440-2451. doi: 10.1093/nar/gkac139. Nucleic Acids Res. 2022. PMID: 35234905 Free PMC article.

10

Computing the relative binding affinity of ligands based on a pairwise binding comparison network.

Yu J, Li Z, Chen G, Kong X, Hu J, Wang D, Cao D, Li Y, Huo R, Wang G, Liu X, Jiang H, Li X, Luo X, Zheng M. Yu J, et al. Among authors: luo x. Nat Comput Sci. 2023 Oct;3(10):860-872. doi: 10.1038/s43588-023-00529-9. Epub 2023 Oct 19. Nat Comput Sci. 2023. PMID: 38177766 Free PMC article.

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